Cargando…

Activation of WNT/β‐catenin signaling results in resistance to a dual PI3K/mTOR inhibitor in colorectal cancer cells harboring PIK3CA mutations

PIK3CA is a frequently mutated gene in cancer, including about ~15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the mechanism of resistance of PIK3CA‐mutant CRC cell l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Ye‐Lim, Kim, Hwang‐Phill, Cho, Young‐Won, Min, Dong‐Wook, Cheon, Seul‐Ki, Lim, Yoo Joo, Song, Sang‐Hyun, Kim, Sung Jin, Han, Sae‐Won, Park, Kyu Joo, Kim, Tae‐You
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2018
Materias:	Cancer Therapy and Prevention
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587482/ https://www.ncbi.nlm.nih.gov/pubmed/29978469 http://dx.doi.org/10.1002/ijc.31662

Ejemplares similares

The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation
por: Kim, Ju Sun, et al.
Publicado: (2017)

mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations
por: Wang, Zhiyong, et al.
Publicado: (2014)

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells
por: Kim, Hee Kyung, et al.
Publicado: (2016)

Axillary response according to neoadjuvant single or dual human epidermal growth factor receptor 2 (HER2) blockade in clinically node‐positive, HER2‐positive breast cancer
por: Cha, Chihwan, et al.
Publicado: (2021)

Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells
por: Cheon, Seul‐Ki, et al.
Publicado: (2018)

Targeting β-catenin overcomes MEK inhibition resistance in colon cancer with KRAS and PIK3CA mutations
por: Moon, Jai-Hee, et al.
Publicado: (2019)

Decreasing trends in thyroid cancer incidence in South Korea: What happened in South Korea?
por: Oh, Chang‐Mo, et al.
Publicado: (2021)

A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
por: Zhu, Ying, et al.
Publicado: (2019)

Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma
por: Seo, Sang Hyun, et al.
Publicado: (2023)

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
por: Mondal, Susmita, et al.
Publicado: (2018)

GPR41 Regulates the Proliferation of BRECs via the PIK3-AKT-mTOR Pathway
por: Meng, Zitong, et al.
Publicado: (2023)

Reliable identification of women with CIN3+ using hrHPV genotyping and methylation markers in a cytology‐screened referral population
por: Leeman, Annemiek, et al.
Publicado: (2018)

A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma
por: Jo, Jung Hyun, et al.
Publicado: (2022)

Sorafenib with ASC‐J9(®) synergistically suppresses the HCC progression via altering the pSTAT3‐CCL2/Bcl2 signals
por: Xu, Junjie, et al.
Publicado: (2016)

Trastuzumab cotreatment improves survival of mice with PC‐3 prostate cancer xenografts treated with the GRPR antagonist (177)Lu‐DOTAGA‐PEG(2)‐RM26
por: Mitran, Bogdan, et al.
Publicado: (2019)

Preventative Effect of Astaxanthin Against Helicobacter pylori-Induced Proliferation of Gastric Epithelial Cells via the Suppression of Wnt/β-Catenin Signaling Pathway.
por: Park, Dayong, et al.
Publicado: (2022)

Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
por: Arend, Rebecca C., et al.
Publicado: (2016)

Astaxanthin Inhibits Matrix Metalloproteinase Expression by Suppressing PI3K/AKT/mTOR Activation in Helicobacter pylori-Infected Gastric Epithelial Cells
por: Lee, Jimin, et al.
Publicado: (2022)

Astaxanthin Inhibits Helicobacter pylori-Induced MMPs Expression and Cell Invasion by Suppressing PI3K-AKT-mTOR Pathways in AGS Cells
por: Lee, Jimin, et al.
Publicado: (2022)

PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors in aging
por: Duggan, Michael R., et al.
Publicado: (2021)

Now or later: Health impacts of delaying single‐dose HPV vaccine implementation in a high‐burden setting
por: Burger, Emily A., et al.
Publicado: (2022)

PIK3CA Mutations in Hepatocellular Carcinoma in Korea
por: Kim, Heesue, et al.
Publicado: (2013)

Pegilodecakin as monotherapy or in combination with anti‐PD‐1 or tyrosine kinase inhibitor in heavily pretreated patients with advanced renal cell carcinoma: Final results of cohorts A, G, H and I of IVY Phase I study
por: Tannir, Nizar M., et al.
Publicado: (2021)

Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer
por: Arend, Rebecca C., et al.
Publicado: (2018)

Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers
por: Reddy, Dhanasekhar, et al.
Publicado: (2020)

Prediagnosis obesity and secondary primary cancer risk in female cancer survivors: A national cohort study
por: Jung, So‐Youn, et al.
Publicado: (2019)

Bempegaldesleukin (BEMPEG; NKTR‐214) efficacy as a single agent and in combination with checkpoint‐inhibitor therapy in mouse models of osteosarcoma
por: Hennessy, Marlene, et al.
Publicado: (2020)

Pilot study of sirolimus in patients with PIK3CA mutant/amplified refractory solid cancer
por: Jung, Ki Sun, et al.
Publicado: (2017)

Enzalutamide and CXCR7 inhibitor combination treatment suppresses cell growth and angiogenic signaling in castration‐resistant prostate cancer models
por: Luo, Yong, et al.
Publicado: (2018)

The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma
por: Kwak, Hyun Jung, et al.
Publicado: (2015)

Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
por: Kim, Joo-Hyun, et al.
Publicado: (2015)

Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations
por: Sivakumar, Smruthy, et al.
Publicado: (2023)

Lactobacilli Differentially Modulate mTOR and Wnt/ β-Catenin Pathways in Different Cancer Cell Lines
por: Taherian-Esfahani, Zahra, et al.
Publicado: (2016)

Metabolome-Wide Reprogramming Modulated by Wnt/β-Catenin Signaling Pathway
por: Park, Soo Jin, et al.
Publicado: (2023)

PI3K/mTOR inhibition promotes the regression of experimental vascular malformations driven by PIK3CA-activating mutations
por: di Blasio, Laura, et al.
Publicado: (2018)

Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
por: Yan, Wei, et al.
Publicado: (2021)

mTOR Signaling Combined with Cancer Stem Cell Markers as a Survival Predictor in Stage II Colorectal Cancer
por: Chang, Ji Young, et al.
Publicado: (2020)

CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities
por: Jung, Ji-Hye, et al.
Publicado: (2016)

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation
por: Fang, Douglas D., et al.
Publicado: (2013)

Use of thermo‐coagulation as an alternative treatment modality in a ‘screen‐and‐treat’ programme of cervical screening in rural Malawi
por: Campbell, Christine, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_itfuke6srj9d7td5e44rar69mf