Cargando…

Gamma‐secretase inhibitor suppressed Notch1 intracellular domain combination with p65 and resulted in the inhibition of the NF‐κB signaling pathway induced by IL‐1β and TNF‐α in nucleus pulposus cells

In this experiment, the cross‐talk betweenNotch and the NF‐κB signaling pathway was examined to reveal the mechanism of slowing down the type II collagen (ColII) and aggrecan degeneration affected by inflammatory cytokines. The expression levels of ColII and aggrecan in the intervertebral disc were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Yao, Mei, Wei, Chen, Jian, Jiang, Tao, Zhou, Zheng, Yin, Guoyong, Fan, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587483/ https://www.ncbi.nlm.nih.gov/pubmed/30367520 http://dx.doi.org/10.1002/jcb.27504

Ejemplares similares

Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-κB signaling pathway
por: Huang, Yao, et al.
Publicado: (2017)

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration
por: Wang, Shengjie, et al.
Publicado: (2017)

Gamma secretase inhibitors of Notch signaling
por: Olsauskas-Kuprys, Roma, et al.
Publicado: (2013)

HO-1 induced autophagy protects against IL-1 β-mediated apoptosis in human nucleus pulposus cells by inhibiting NF-κB
por: Zou, Luetao, et al.
Publicado: (2020)

Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway
por: Luo, Xi, et al.
Publicado: (2021)

Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway
por: Xie, Tian, et al.
Publicado: (2022)

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats
por: Lan, Wei-ren, et al.
Publicado: (2019)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

Berberine prevents human nucleus pulposus cells from IL-1β-induced extracellular matrix degradation and apoptosis by inhibiting the NF-κB pathway
por: Lu, Lin, et al.
Publicado: (2019)

17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway
por: Li, Pei, et al.
Publicado: (2017)

Inhibition of gamma-secretase in Notch1 signaling pathway as a novel treatment for ovarian cancer
por: Feng, Zhaoyi, et al.
Publicado: (2016)

Effect of a low-frequency pulsed electromagnetic field on expression and secretion of IL-1β and TNF-α in nucleus pulposus cells
por: Zou, Jun, et al.
Publicado: (2017)

Effects of the NF-κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration
por: Zhang, Litao, et al.
Publicado: (2020)

Overexpression of LMP-1 Decreases Apoptosis in Human Nucleus Pulposus Cells via Suppressing the NF-κB Signaling Pathway
por: Liu, Yuan, et al.
Publicado: (2020)

Andrographolide mitigates IL-1β-induced human nucleus pulposus cells degeneration through the TLR4/MyD88/NF-κB signaling pathway
por: Zhang, Lilian, et al.
Publicado: (2018)

Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma
por: Abedin, Yasmin, et al.
Publicado: (2022)

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana
por: Smolarkiewicz, Michalina, et al.
Publicado: (2014)

Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment
por: Yu, Wei, et al.
Publicado: (2018)

SDF-1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF-κB pathway
por: LIU, ZONGCHAO, et al.
Publicado: (2016)

Follistatin-like protein 1 promotes inflammatory reactions in nucleus pulposus cells by interacting with the MAPK and NFκB signaling pathways
por: Liu, Yi, et al.
Publicado: (2017)

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2019)

LIPUS inhibits inflammation and catabolism through the NF‐κB pathway in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2021)

Higenamine inhibits IL-1β-induced inflammation in human nucleus pulposus cells
por: Bai, Xiaoliang, et al.
Publicado: (2019)

NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer
por: Wang, Wenjing, et al.
Publicado: (2023)

Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF-κB
por: Zhang, Kai, et al.
Publicado: (2019)

S100A9 induces nucleus pulposus cell degeneration through activation of the NF‐κB signaling pathway
por: Guo, Song, et al.
Publicado: (2021)

Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence
por: Huang, Xin, et al.
Publicado: (2022)

Rosuvastatin suppresses TNF-α-induced matrix catabolism, pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells: Role of rosuvastatin in alleviating intervertebral disc degeneration
por: Chen, Weijian, et al.
Publicado: (2023)

A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells
por: Hiyama, Akihiko, et al.
Publicado: (2013)

Expression and Significance of TNF-α and NF-κB/p65 in Cutaneous Lichen Planus
por: Chen, Jun Fang, et al.
Publicado: (2022)

Moracin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf2/HO-1 and NF-κB/TGF-β pathway
por: Gu, Ronghe, et al.
Publicado: (2019)

Aloin Regulates Matrix Metabolism and Apoptosis in Human Nucleus Pulposus Cells via the TAK1/NF-κB/NLRP3 Signaling Pathway
por: Chen, Taiqiu, et al.
Publicado: (2022)

Effects of a gamma‐secretase inhibitor of notch signalling on transforming growth factor β1‐induced urethral fibrosis
por: Huang, Shanlong, et al.
Publicado: (2021)

Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression
por: Suzuki, Shinsuke, et al.
Publicado: (2022)

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
por: XU, KANG, et al.
Publicado: (2015)

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis
por: Lu, Peng, et al.
Publicado: (2023)

Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity
por: Sparling, David P., et al.
Publicado: (2015)

Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification
por: Wang, Zheng, et al.
Publicado: (2023)

Selective inhibitors of the PSEN1–gamma-secretase complex
por: Serneels, Lutgarde, et al.
Publicado: (2023)

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway
por: Zhang, Cun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_h6sn36vi0f53phu2duun6l4pmu