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Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis

OBJECTIVE: Treat‐to‐target strategies have improved outcomes in rheumatic diseases. In psoriatic arthritis (PsA), the proposed targets are the multidimensional target minimal disease activity (MDA) and the articular target Disease Activity index for PsA (DAPSA). The aim of this study was to compare...

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Autores principales: Wervers, Kim, Vis, Marijn, Tchetveriko, Ilja, Gerards, Andreas H., Kok, Marc R., Appels, Cathelijne W. Y., van der Graaff, Wiebo L., van Groenendael, Johannes H. L. M., Korswagen, Lindy‐Anne, Veris‐van Dieren, Josien J., Hazes, Johanna M. W., Luime, Jolanda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587485/
https://www.ncbi.nlm.nih.gov/pubmed/29609220
http://dx.doi.org/10.1002/acr.23571
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author Wervers, Kim
Vis, Marijn
Tchetveriko, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy‐Anne
Veris‐van Dieren, Josien J.
Hazes, Johanna M. W.
Luime, Jolanda J.
author_facet Wervers, Kim
Vis, Marijn
Tchetveriko, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy‐Anne
Veris‐van Dieren, Josien J.
Hazes, Johanna M. W.
Luime, Jolanda J.
author_sort Wervers, Kim
collection PubMed
description OBJECTIVE: Treat‐to‐target strategies have improved outcomes in rheumatic diseases. In psoriatic arthritis (PsA), the proposed targets are the multidimensional target minimal disease activity (MDA) and the articular target Disease Activity index for PsA (DAPSA). The aim of this study was to compare the disease burden of PsA in patients with low disease activity according to the 2 definitions, MDA and DAPSA low disease activity (DAPSA‐LDA), 1 year after diagnosis. METHODS: We obtained data on MDA, DAPSA‐LDA and disease burden 1 year after diagnosis for patients included in the Dutch southwest early PsA cohort. Disease burden was assessed in 2 domains: “Body functions,” including the Short Form 36 bodily pain (SF‐36 BP) measure, and “Activity,” including the Health Assessment Questionnaire (HAQ). RESULTS: Among the 292 patients included, 48% achieved MDA and 74% achieved DAPSA‐LDA. Average scores for Body functions and Activity were better in patients who achieved MDA and those who achieved DAPSA‐LDA. The scores were significantly better in the 46% of patients who achieved both MDA and DAPSA‐LDA than in the 29% of patients who achieved only DAPSA‐LDA. The average SF‐36 BP score was higher in patients achieving both targets (73.8; 95% confidence interval [95% CI] 71.1‐76.5) than in patients achieving only DAPSA‐LDA (57.6; 95% CI 54.5‐60.8). Similarly, mean HAQ scores measuring Activity were 0.21 (95% CI 0.15‐0.26) and 0.63 (95% CI 0.53‐0.72), respectively. CONCLUSION: Among patients with newly diagnosed PsA, 48% achieved MDA and 74% achieved DAPSA‐LDA after 1 year of receiving usual care. The average disease burden was better in patients who achieved MDA and those who achieved DAPSA‐LDA. Also, patients who achieved only DAPSA‐LDA reported worse outcomes than those who also achieved MDA.
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spelling pubmed-65874852019-07-02 Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis Wervers, Kim Vis, Marijn Tchetveriko, Ilja Gerards, Andreas H. Kok, Marc R. Appels, Cathelijne W. Y. van der Graaff, Wiebo L. van Groenendael, Johannes H. L. M. Korswagen, Lindy‐Anne Veris‐van Dieren, Josien J. Hazes, Johanna M. W. Luime, Jolanda J. Arthritis Care Res (Hoboken) Psoriatic Arthritis OBJECTIVE: Treat‐to‐target strategies have improved outcomes in rheumatic diseases. In psoriatic arthritis (PsA), the proposed targets are the multidimensional target minimal disease activity (MDA) and the articular target Disease Activity index for PsA (DAPSA). The aim of this study was to compare the disease burden of PsA in patients with low disease activity according to the 2 definitions, MDA and DAPSA low disease activity (DAPSA‐LDA), 1 year after diagnosis. METHODS: We obtained data on MDA, DAPSA‐LDA and disease burden 1 year after diagnosis for patients included in the Dutch southwest early PsA cohort. Disease burden was assessed in 2 domains: “Body functions,” including the Short Form 36 bodily pain (SF‐36 BP) measure, and “Activity,” including the Health Assessment Questionnaire (HAQ). RESULTS: Among the 292 patients included, 48% achieved MDA and 74% achieved DAPSA‐LDA. Average scores for Body functions and Activity were better in patients who achieved MDA and those who achieved DAPSA‐LDA. The scores were significantly better in the 46% of patients who achieved both MDA and DAPSA‐LDA than in the 29% of patients who achieved only DAPSA‐LDA. The average SF‐36 BP score was higher in patients achieving both targets (73.8; 95% confidence interval [95% CI] 71.1‐76.5) than in patients achieving only DAPSA‐LDA (57.6; 95% CI 54.5‐60.8). Similarly, mean HAQ scores measuring Activity were 0.21 (95% CI 0.15‐0.26) and 0.63 (95% CI 0.53‐0.72), respectively. CONCLUSION: Among patients with newly diagnosed PsA, 48% achieved MDA and 74% achieved DAPSA‐LDA after 1 year of receiving usual care. The average disease burden was better in patients who achieved MDA and those who achieved DAPSA‐LDA. Also, patients who achieved only DAPSA‐LDA reported worse outcomes than those who also achieved MDA. John Wiley and Sons Inc. 2018-11-28 2018-12 /pmc/articles/PMC6587485/ /pubmed/29609220 http://dx.doi.org/10.1002/acr.23571 Text en © 2018 The Authors. Arthritis Care & Research published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Psoriatic Arthritis
Wervers, Kim
Vis, Marijn
Tchetveriko, Ilja
Gerards, Andreas H.
Kok, Marc R.
Appels, Cathelijne W. Y.
van der Graaff, Wiebo L.
van Groenendael, Johannes H. L. M.
Korswagen, Lindy‐Anne
Veris‐van Dieren, Josien J.
Hazes, Johanna M. W.
Luime, Jolanda J.
Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title_full Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title_fullStr Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title_full_unstemmed Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title_short Burden of Psoriatic Arthritis According to Different Definitions of Disease Activity: Comparing Minimal Disease Activity and the Disease Activity Index for Psoriatic Arthritis
title_sort burden of psoriatic arthritis according to different definitions of disease activity: comparing minimal disease activity and the disease activity index for psoriatic arthritis
topic Psoriatic Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587485/
https://www.ncbi.nlm.nih.gov/pubmed/29609220
http://dx.doi.org/10.1002/acr.23571
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