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Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study

It is unclear whether weight change during adulthood affects the risk of obesity‐related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change dur...

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Autores principales: Wakamatsu, Mano, Sugawara, Yumi, Zhang, Shu, Tanji, Fumiya, Tomata, Yasutake, Tsuji, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587529/
https://www.ncbi.nlm.nih.gov/pubmed/29992563
http://dx.doi.org/10.1002/ijc.31743
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author Wakamatsu, Mano
Sugawara, Yumi
Zhang, Shu
Tanji, Fumiya
Tomata, Yasutake
Tsuji, Ichiro
author_facet Wakamatsu, Mano
Sugawara, Yumi
Zhang, Shu
Tanji, Fumiya
Tomata, Yasutake
Tsuji, Ichiro
author_sort Wakamatsu, Mano
collection PubMed
description It is unclear whether weight change during adulthood affects the risk of obesity‐related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change during adulthood and the risk of obesity‐related cancer among Japanese by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. A total of 78,743 persons (40,422 women and 38,321 men) aged 40–79 years participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994. Weight change since age 20 was divided into four categories (weight loss; stable weight; moderate weight gain; high weight gain). Cox proportional hazards regression analysis was used to estimate the multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for obesity‐related cancer incidence. During 1,057,899 person‐years of follow up, 4,467 cases of obesity‐related cancer (women; 1,916 cases, men; 2,551cases) were identified. In women, compared to the stable weight, weight gain was associated with an increased risk of obesity‐related cancer (moderate weight gain; HRs = 1.10, 95%CIs: 0.97–1.26, high weight gain; HRs = 1.29, 95%CIs: 1.14–1.47). The results indicate that weight gain since age 20 was associated with a significantly increased risk of obesity‐related cancer among Japanese women. By contrast, in men, our study found that weight change is not associated with the incidence of obesity‐related cancer.
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spelling pubmed-65875292019-07-02 Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study Wakamatsu, Mano Sugawara, Yumi Zhang, Shu Tanji, Fumiya Tomata, Yasutake Tsuji, Ichiro Int J Cancer Cancer Epidemiology It is unclear whether weight change during adulthood affects the risk of obesity‐related cancers such as those of the esophagus, colorectum, pancreas, breast, endometrium, and kidney among Japanese, where obesity is less frequent and less severe. We examined the association between weight change during adulthood and the risk of obesity‐related cancer among Japanese by conducting a pooled analysis of two prospective studies of residents in Miyagi Prefecture, Japan. A total of 78,743 persons (40,422 women and 38,321 men) aged 40–79 years participated in the Miyagi Cohort Study in 1990 and in the Ohsaki Cohort Study in 1994. Weight change since age 20 was divided into four categories (weight loss; stable weight; moderate weight gain; high weight gain). Cox proportional hazards regression analysis was used to estimate the multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) for obesity‐related cancer incidence. During 1,057,899 person‐years of follow up, 4,467 cases of obesity‐related cancer (women; 1,916 cases, men; 2,551cases) were identified. In women, compared to the stable weight, weight gain was associated with an increased risk of obesity‐related cancer (moderate weight gain; HRs = 1.10, 95%CIs: 0.97–1.26, high weight gain; HRs = 1.29, 95%CIs: 1.14–1.47). The results indicate that weight gain since age 20 was associated with a significantly increased risk of obesity‐related cancer among Japanese women. By contrast, in men, our study found that weight change is not associated with the incidence of obesity‐related cancer. John Wiley & Sons, Inc. 2018-10-30 2019-03-01 /pmc/articles/PMC6587529/ /pubmed/29992563 http://dx.doi.org/10.1002/ijc.31743 Text en © 2018 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cancer Epidemiology
Wakamatsu, Mano
Sugawara, Yumi
Zhang, Shu
Tanji, Fumiya
Tomata, Yasutake
Tsuji, Ichiro
Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title_full Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title_fullStr Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title_full_unstemmed Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title_short Weight change since age 20 and incident risk of obesity‐related cancer in Japan: a pooled analysis of the Miyagi Cohort Study and the Ohsaki Cohort Study
title_sort weight change since age 20 and incident risk of obesity‐related cancer in japan: a pooled analysis of the miyagi cohort study and the ohsaki cohort study
topic Cancer Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587529/
https://www.ncbi.nlm.nih.gov/pubmed/29992563
http://dx.doi.org/10.1002/ijc.31743
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