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Tumor suppressors BTG1 and BTG2: Beyond growth control

Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation genes more than two decades ago, their protein products have been implicated in a variety of cellular processes including cell division, DNA repair, transcriptional regulation and messenger RNA stability. In...

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Detalles Bibliográficos
Autores principales: Yuniati, Laurensia, Scheijen, Blanca, van der Meer, Laurens T., van Leeuwen, Frank N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587536/
https://www.ncbi.nlm.nih.gov/pubmed/30350856
http://dx.doi.org/10.1002/jcp.27407
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author Yuniati, Laurensia
Scheijen, Blanca
van der Meer, Laurens T.
van Leeuwen, Frank N.
author_facet Yuniati, Laurensia
Scheijen, Blanca
van der Meer, Laurens T.
van Leeuwen, Frank N.
author_sort Yuniati, Laurensia
collection PubMed
description Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation genes more than two decades ago, their protein products have been implicated in a variety of cellular processes including cell division, DNA repair, transcriptional regulation and messenger RNA stability. In addition to affecting differentiation during development and in the adult, BTG proteins play an important role in maintaining homeostasis under conditions of cellular stress. Genomic profiling of B‐cell leukemia and lymphoma has put BTG1 and BTG2 in the spotlight, since both genes are frequently deleted or mutated in these malignancies, pointing towards a role as tumor suppressors. Moreover, in solid tumors, reduced expression of BTG1 or BTG2 is often correlated with malignant cell behavior and poor treatment outcome. Recent studies have uncovered novel roles for BTG1 and BTG2 in genotoxic and integrated stress responses, as well as during hematopoiesis. This review summarizes what is currently known about the roles of BTG1 and BTG2 in these and other cellular processes. In addition, we will highlight the molecular mechanisms and biological consequences of BTG1 and BTG2 deregulation during cancer progression and elaborate on the potential clinical implications of these findings.
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spelling pubmed-65875362019-07-02 Tumor suppressors BTG1 and BTG2: Beyond growth control Yuniati, Laurensia Scheijen, Blanca van der Meer, Laurens T. van Leeuwen, Frank N. J Cell Physiol Mini‐reviews Since the identification of B‐cell translocation gene 1 (BTG1) and BTG2 as antiproliferation genes more than two decades ago, their protein products have been implicated in a variety of cellular processes including cell division, DNA repair, transcriptional regulation and messenger RNA stability. In addition to affecting differentiation during development and in the adult, BTG proteins play an important role in maintaining homeostasis under conditions of cellular stress. Genomic profiling of B‐cell leukemia and lymphoma has put BTG1 and BTG2 in the spotlight, since both genes are frequently deleted or mutated in these malignancies, pointing towards a role as tumor suppressors. Moreover, in solid tumors, reduced expression of BTG1 or BTG2 is often correlated with malignant cell behavior and poor treatment outcome. Recent studies have uncovered novel roles for BTG1 and BTG2 in genotoxic and integrated stress responses, as well as during hematopoiesis. This review summarizes what is currently known about the roles of BTG1 and BTG2 in these and other cellular processes. In addition, we will highlight the molecular mechanisms and biological consequences of BTG1 and BTG2 deregulation during cancer progression and elaborate on the potential clinical implications of these findings. John Wiley and Sons Inc. 2018-10-23 2019-05 /pmc/articles/PMC6587536/ /pubmed/30350856 http://dx.doi.org/10.1002/jcp.27407 Text en © 2018 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini‐reviews
Yuniati, Laurensia
Scheijen, Blanca
van der Meer, Laurens T.
van Leeuwen, Frank N.
Tumor suppressors BTG1 and BTG2: Beyond growth control
title Tumor suppressors BTG1 and BTG2: Beyond growth control
title_full Tumor suppressors BTG1 and BTG2: Beyond growth control
title_fullStr Tumor suppressors BTG1 and BTG2: Beyond growth control
title_full_unstemmed Tumor suppressors BTG1 and BTG2: Beyond growth control
title_short Tumor suppressors BTG1 and BTG2: Beyond growth control
title_sort tumor suppressors btg1 and btg2: beyond growth control
topic Mini‐reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587536/
https://www.ncbi.nlm.nih.gov/pubmed/30350856
http://dx.doi.org/10.1002/jcp.27407
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