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Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis
BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) was recently proposed as a prognostic factor of ovarian cancer. However, prognostic value of the LMR in ovarian cancer remains inconclusive. The study aimed to assess prognostic value of the LMR in ovarian cancer. METHODS: Seven common databases were co...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587575/ https://www.ncbi.nlm.nih.gov/pubmed/31192919 http://dx.doi.org/10.1097/MD.0000000000015876 |
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author | Lu, Cong Zhou, Long Ouyang, Jing Yang, Huajing |
author_facet | Lu, Cong Zhou, Long Ouyang, Jing Yang, Huajing |
author_sort | Lu, Cong |
collection | PubMed |
description | BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) was recently proposed as a prognostic factor of ovarian cancer. However, prognostic value of the LMR in ovarian cancer remains inconclusive. The study aimed to assess prognostic value of the LMR in ovarian cancer. METHODS: Seven common databases were comprehensively searched for relevant studies. The analyses were performed for overall survival (OS), progression-free survival (PFS) and clinical parameters. The hazard ratio (HR) and 95% confidence interval (CI) were used to analyze OS and PFS. RESULTS: A total of 2343 patients with ovarian cancer were included in this meta-analysis. The results showed that a low LMR predicted shorter OS (HR = 1.81, 95% CI = 1.38–2.37, P < .01) and PFS (HR = 1.65 95% CI = 1.46–1.85, P < .01) when compared to a high LMR in ovarian cancer. Besides, a low LMR was significantly associated with advanced clinical stage (P < .01), earlier lymph node metastasis (P = .01), higher carbohydrate antigen-125 levels (P < .01), larger residual tumor (P < .01) and worse chemosensitivity (P < .01) when compared to a high LMR in ovarian cancer. CONCLUSION: Low LMR was associated with unfavorable survival in patients with ovarian cancer. LMR could serve as a prognostic biomarker of ovarian cancer. |
format | Online Article Text |
id | pubmed-6587575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-65875752019-06-24 Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis Lu, Cong Zhou, Long Ouyang, Jing Yang, Huajing Medicine (Baltimore) Research Article BACKGROUND: Lymphocyte-to-monocyte ratio (LMR) was recently proposed as a prognostic factor of ovarian cancer. However, prognostic value of the LMR in ovarian cancer remains inconclusive. The study aimed to assess prognostic value of the LMR in ovarian cancer. METHODS: Seven common databases were comprehensively searched for relevant studies. The analyses were performed for overall survival (OS), progression-free survival (PFS) and clinical parameters. The hazard ratio (HR) and 95% confidence interval (CI) were used to analyze OS and PFS. RESULTS: A total of 2343 patients with ovarian cancer were included in this meta-analysis. The results showed that a low LMR predicted shorter OS (HR = 1.81, 95% CI = 1.38–2.37, P < .01) and PFS (HR = 1.65 95% CI = 1.46–1.85, P < .01) when compared to a high LMR in ovarian cancer. Besides, a low LMR was significantly associated with advanced clinical stage (P < .01), earlier lymph node metastasis (P = .01), higher carbohydrate antigen-125 levels (P < .01), larger residual tumor (P < .01) and worse chemosensitivity (P < .01) when compared to a high LMR in ovarian cancer. CONCLUSION: Low LMR was associated with unfavorable survival in patients with ovarian cancer. LMR could serve as a prognostic biomarker of ovarian cancer. Wolters Kluwer Health 2019-06-14 /pmc/articles/PMC6587575/ /pubmed/31192919 http://dx.doi.org/10.1097/MD.0000000000015876 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Lu, Cong Zhou, Long Ouyang, Jing Yang, Huajing Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title | Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title_full | Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title_fullStr | Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title_full_unstemmed | Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title_short | Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis |
title_sort | prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587575/ https://www.ncbi.nlm.nih.gov/pubmed/31192919 http://dx.doi.org/10.1097/MD.0000000000015876 |
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