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Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective

Tissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, b...

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Detalles Bibliográficos
Autores principales: Viji Babu, Prem Kumar, Radmacher, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587663/
https://www.ncbi.nlm.nih.gov/pubmed/31258462
http://dx.doi.org/10.3389/fnins.2019.00600
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author Viji Babu, Prem Kumar
Radmacher, Manfred
author_facet Viji Babu, Prem Kumar
Radmacher, Manfred
author_sort Viji Babu, Prem Kumar
collection PubMed
description Tissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, biophysicists, and others in this topic. Atomic force microscopy (AFM) both as an imaging and as a mechanical tool provides an excellent opportunity to study soft biological samples such as live brain tissues. Here we review the principles of AFM, the performance of AFM in tissue imaging and mechanical mapping of cells and tissues, and finally opening the prospects and challenges of probing the biophysical properties of brain tissue using AFM.
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spelling pubmed-65876632019-06-28 Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective Viji Babu, Prem Kumar Radmacher, Manfred Front Neurosci Neuroscience Tissue morphology and mechanics are crucial to the regulation of organ function. Investigating the exceptionally complex tissue of the brain at the sub-micron scale is challenging due to the complex structure and softness of this tissue, despite the large interest of biologists, medical engineers, biophysicists, and others in this topic. Atomic force microscopy (AFM) both as an imaging and as a mechanical tool provides an excellent opportunity to study soft biological samples such as live brain tissues. Here we review the principles of AFM, the performance of AFM in tissue imaging and mechanical mapping of cells and tissues, and finally opening the prospects and challenges of probing the biophysical properties of brain tissue using AFM. Frontiers Media S.A. 2019-06-14 /pmc/articles/PMC6587663/ /pubmed/31258462 http://dx.doi.org/10.3389/fnins.2019.00600 Text en Copyright © 2019 Viji Babu and Radmacher. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Viji Babu, Prem Kumar
Radmacher, Manfred
Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title_full Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title_fullStr Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title_full_unstemmed Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title_short Mechanics of Brain Tissues Studied by Atomic Force Microscopy: A Perspective
title_sort mechanics of brain tissues studied by atomic force microscopy: a perspective
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587663/
https://www.ncbi.nlm.nih.gov/pubmed/31258462
http://dx.doi.org/10.3389/fnins.2019.00600
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