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Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AN...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/ https://www.ncbi.nlm.nih.gov/pubmed/30357923 http://dx.doi.org/10.1111/jop.12792 |
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author | Gu, Xiaolian Coates, Philip J. Boldrup, Linda Wang, Lixiao Krejci, Adam Hupp, Ted Fahraeus, Robin Norberg‐Spaak, Lena Sgaramella, Nicola Wilms, Torben Nylander, Karin |
author_facet | Gu, Xiaolian Coates, Philip J. Boldrup, Linda Wang, Lixiao Krejci, Adam Hupp, Ted Fahraeus, Robin Norberg‐Spaak, Lena Sgaramella, Nicola Wilms, Torben Nylander, Karin |
author_sort | Gu, Xiaolian |
collection | PubMed |
description | BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AND METHODS: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (≤40 years) and five elderly patients (≥50 years) using global RNA sequencing and whole‐exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. RESULTS: In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low‐CNV (n = 5) compared to high‐CNV (n = 11) burden (P = 0.044). CONCLUSIONS: Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT. |
format | Online Article Text |
id | pubmed-6587711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65877112019-07-02 Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue Gu, Xiaolian Coates, Philip J. Boldrup, Linda Wang, Lixiao Krejci, Adam Hupp, Ted Fahraeus, Robin Norberg‐Spaak, Lena Sgaramella, Nicola Wilms, Torben Nylander, Karin J Oral Pathol Med Original Articles BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AND METHODS: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (≤40 years) and five elderly patients (≥50 years) using global RNA sequencing and whole‐exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. RESULTS: In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low‐CNV (n = 5) compared to high‐CNV (n = 11) burden (P = 0.044). CONCLUSIONS: Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT. John Wiley and Sons Inc. 2018-11-02 2019-01 /pmc/articles/PMC6587711/ /pubmed/30357923 http://dx.doi.org/10.1111/jop.12792 Text en © 2018 The Authors. Journal of Oral Pathology & Medicine Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles Gu, Xiaolian Coates, Philip J. Boldrup, Linda Wang, Lixiao Krejci, Adam Hupp, Ted Fahraeus, Robin Norberg‐Spaak, Lena Sgaramella, Nicola Wilms, Torben Nylander, Karin Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title | Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title_full | Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title_fullStr | Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title_full_unstemmed | Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title_short | Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
title_sort | copy number variation: a prognostic marker for young patients with squamous cell carcinoma of the oral tongue |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/ https://www.ncbi.nlm.nih.gov/pubmed/30357923 http://dx.doi.org/10.1111/jop.12792 |
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