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Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue

BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AN...

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Autores principales: Gu, Xiaolian, Coates, Philip J., Boldrup, Linda, Wang, Lixiao, Krejci, Adam, Hupp, Ted, Fahraeus, Robin, Norberg‐Spaak, Lena, Sgaramella, Nicola, Wilms, Torben, Nylander, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/
https://www.ncbi.nlm.nih.gov/pubmed/30357923
http://dx.doi.org/10.1111/jop.12792
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author Gu, Xiaolian
Coates, Philip J.
Boldrup, Linda
Wang, Lixiao
Krejci, Adam
Hupp, Ted
Fahraeus, Robin
Norberg‐Spaak, Lena
Sgaramella, Nicola
Wilms, Torben
Nylander, Karin
author_facet Gu, Xiaolian
Coates, Philip J.
Boldrup, Linda
Wang, Lixiao
Krejci, Adam
Hupp, Ted
Fahraeus, Robin
Norberg‐Spaak, Lena
Sgaramella, Nicola
Wilms, Torben
Nylander, Karin
author_sort Gu, Xiaolian
collection PubMed
description BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AND METHODS: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (≤40 years) and five elderly patients (≥50 years) using global RNA sequencing and whole‐exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. RESULTS: In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low‐CNV (n = 5) compared to high‐CNV (n = 11) burden (P = 0.044). CONCLUSIONS: Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT.
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spelling pubmed-65877112019-07-02 Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue Gu, Xiaolian Coates, Philip J. Boldrup, Linda Wang, Lixiao Krejci, Adam Hupp, Ted Fahraeus, Robin Norberg‐Spaak, Lena Sgaramella, Nicola Wilms, Torben Nylander, Karin J Oral Pathol Med Original Articles BACKGROUND: The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. MATERIALS AND METHODS: To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (≤40 years) and five elderly patients (≥50 years) using global RNA sequencing and whole‐exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. RESULTS: In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low‐CNV (n = 5) compared to high‐CNV (n = 11) burden (P = 0.044). CONCLUSIONS: Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT. John Wiley and Sons Inc. 2018-11-02 2019-01 /pmc/articles/PMC6587711/ /pubmed/30357923 http://dx.doi.org/10.1111/jop.12792 Text en © 2018 The Authors. Journal of Oral Pathology & Medicine Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Gu, Xiaolian
Coates, Philip J.
Boldrup, Linda
Wang, Lixiao
Krejci, Adam
Hupp, Ted
Fahraeus, Robin
Norberg‐Spaak, Lena
Sgaramella, Nicola
Wilms, Torben
Nylander, Karin
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title_full Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title_fullStr Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title_full_unstemmed Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title_short Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
title_sort copy number variation: a prognostic marker for young patients with squamous cell carcinoma of the oral tongue
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587711/
https://www.ncbi.nlm.nih.gov/pubmed/30357923
http://dx.doi.org/10.1111/jop.12792
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