The analgesic efficacy of morphine varies with rat strain and experimental pain model: implications for target validation efforts in pain drug discovery

BACKGROUND: Translating efficacy of analgesic drugs from animal models to humans remains challenging. Reasons are multifaceted, but lack of sufficiently rigorous preclinical study design criteria and phenotypically relevant models may be partly responsible. To begin to address this fundamental issue...

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Detalles Bibliográficos
Autores principales: Hestehave, Sara, Abelson, Klas S. P., Brønnum Pedersen, Tina, Munro, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587867/
https://www.ncbi.nlm.nih.gov/pubmed/30318662
http://dx.doi.org/10.1002/ejp.1327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587867/
https://www.ncbi.nlm.nih.gov/pubmed/30318662
http://dx.doi.org/10.1002/ejp.1327

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