Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study

It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self‐reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels w...

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Autores principales: Li‐Gao, Ruifang, Morelli, Vânia M., Lijfering, Willem M., Cannegieter, Suzanne C., Rosendaal, Frits R., van Hylckama Vlieg, Astrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Platelets, Haemostasis and Thrombosis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587875/
https://www.ncbi.nlm.nih.gov/pubmed/30478992
http://dx.doi.org/10.1111/bjh.15599
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author Li‐Gao, Ruifang
Morelli, Vânia M.
Lijfering, Willem M.
Cannegieter, Suzanne C.
Rosendaal, Frits R.
van Hylckama Vlieg, Astrid
author_facet Li‐Gao, Ruifang
Morelli, Vânia M.
Lijfering, Willem M.
Cannegieter, Suzanne C.
Rosendaal, Frits R.
van Hylckama Vlieg, Astrid
author_sort Li‐Gao, Ruifang
collection PubMed
description It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self‐reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [<6·1 (reference), 6·1–7·0 (2nd), ≥7·0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0·98 (0·69–1·37) 2nd vs. reference, 0·97 (0·58–1·63) 3rd vs. reference] nor self‐reported diabetes [1·12 (0·80–1·58)] were associated with an increased risk of a first VT.
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spelling pubmed-65878752019-07-02 Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study Li‐Gao, Ruifang Morelli, Vânia M. Lijfering, Willem M. Cannegieter, Suzanne C. Rosendaal, Frits R. van Hylckama Vlieg, Astrid Br J Haematol Platelets, Haemostasis and Thrombosis It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self‐reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [<6·1 (reference), 6·1–7·0 (2nd), ≥7·0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0·98 (0·69–1·37) 2nd vs. reference, 0·97 (0·58–1·63) 3rd vs. reference] nor self‐reported diabetes [1·12 (0·80–1·58)] were associated with an increased risk of a first VT. John Wiley and Sons Inc. 2018-11-27 2019-02 /pmc/articles/PMC6587875/ /pubmed/30478992 http://dx.doi.org/10.1111/bjh.15599 Text en © 2018 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Platelets, Haemostasis and Thrombosis
Li‐Gao, Ruifang
Morelli, Vânia M.
Lijfering, Willem M.
Cannegieter, Suzanne C.
Rosendaal, Frits R.
van Hylckama Vlieg, Astrid
Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title_full Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title_fullStr Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title_full_unstemmed Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title_short Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case‐control study
title_sort glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the mega case‐control study
topic Platelets, Haemostasis and Thrombosis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587875/
https://www.ncbi.nlm.nih.gov/pubmed/30478992
http://dx.doi.org/10.1111/bjh.15599
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