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Highly sensitive and rapid determination of tacrolimus in peripheral blood mononuclear cells by liquid chromatography–tandem mass spectrometry

After solid organ transplantation, tacrolimus is given to prevent rejection. Therapeutic drug monitoring is used to reach target concentrations of tacrolimus in whole blood. Because the site of action of tacrolimus is the lymphocyte, and tacrolimus binds ~80% to erythrocytes, the intracellular tacro...

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Detalles Bibliográficos
Autores principales:	Bahmany, Soma, de Wit, Lucia E.A., Hesselink, Dennis A., van Gelder, Teun, Shuker, Nauras M., Baan, Carla, van der Nagel, Bart C.H., Koch, Birgit C.P., de Winter, Brenda C.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587946/ https://www.ncbi.nlm.nih.gov/pubmed/30362145 http://dx.doi.org/10.1002/bmc.4416

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