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Thrombin cleavage of osteopontin controls activation of hepatic stellate cells and is essential for liver fibrogenesis

Liver biopsy is the current reliable way of evaluating liver fibrosis. However, no specific sera biomarker could be applied in clinical diagnosis. As the pivotal role of osteopontin (OPN) reported in numerous liver diseases, thrombin‐cleaved OPN (Thr‐OPN) exposes an integrin‐binding motif that promo...

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Detalles Bibliográficos
Autores principales:	Cui, Guangying, Chen, Jianing, Wu, Zhongwen, Huang, Haijun, Wang, Lin, Liang, Yan, Zeng, Ping, Yang, Jiezuan, Uede, Toshimitsu, Diao, Hongyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588095/ https://www.ncbi.nlm.nih.gov/pubmed/30350863 http://dx.doi.org/10.1002/jcp.27571

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