The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis

Wilms tumour is a paediatric malignancy with features of halted kidney development. Here, we demonstrate that the Iroquois homeobox genes IRX3 and IRX5 are essential for mammalian nephrogenesis and govern the differentiation of Wilms tumour. Knock‐out Irx3 (−) /Irx5 (−) mice showed a strongly reduce...

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Detalles Bibliográficos
Autores principales: Holmquist Mengelbier, Linda, Lindell‐Munther, Simon, Yasui, Hiroaki, Jansson, Caroline, Esfandyari, Javanshir, Karlsson, Jenny, Lau, Kimberly, Hui, Chi‐chung, Bexell, Daniel, Hopyan, Sevan, Gisselsson, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588170/
https://www.ncbi.nlm.nih.gov/pubmed/30246301
http://dx.doi.org/10.1002/path.5171

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