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High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes
Intrarenal hypoxia develops within a few days after the onset of insulinopenic diabetes in an experimental animal model (ie, a model of type-1 diabetes). Although diabetes-induced hypoxia results in increased renal lactate formation, mitochondrial function is well maintained, a condition commonly re...
Autores principales: | Laustsen, Christoffer, Lipsø, Kasper, Østergaard, Jakob Appel, Nielsen, Per Mose, Bertelsen, Lotte Bonde, Flyvbjerg, Allan, Pedersen, Michael, Palm, Fredrik, Ardenkjær-Larsen, Jan Henrik |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Grapho Publications, LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588198/ https://www.ncbi.nlm.nih.gov/pubmed/31245545 http://dx.doi.org/10.18383/j.tom.2019.00003 |
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