A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I

During meiotic prophase I, double-strand breaks (DSBs) initiate homologous recombination leading to non-crossovers (NCOs) and crossovers (COs). In mouse, 10% of DSBs are designated to become COs, primarily through a pathway dependent on the MLH1-MLH3 heterodimer (MutLγ). Mlh3 contains an endonucleas...

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Detalles Bibliográficos
Autores principales: Toledo, Melissa, Sun, Xianfei, Brieño-Enríquez, Miguel A., Raghavan, Vandana, Gray, Stephen, Pea, Jeffrey, Milano, Carolyn R., Venkatesh, Anita, Patel, Lekha, Borst, Peter L., Alani, Eric, Cohen, Paula E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588253/
https://www.ncbi.nlm.nih.gov/pubmed/31170160
http://dx.doi.org/10.1371/journal.pgen.1008177

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