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HSP90 Inhibitor, NVP-AUY922, Improves Myelination in Vitro and Supports the Maintenance of Myelinated Axons in Neuropathic Mice

[Image: see text] Hereditary demyelinating neuropathies linked to peripheral myelin protein 22 (PMP22) involve the disruption of normal protein trafficking and are therefore relevant targets for chaperone therapy. Using a small molecule HSP90 inhibitor, EC137, in cell culture models, we previously v...

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Detalles Bibliográficos
Autores principales:	Chittoor-Vinod, Vinita G., Bazick, Hannah, Todd, Adrian G., Falk, Darin, Morelli, Kathryn H., Burgess, Robert W., Foster, Thomas C., Notterpek, Lucia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588339/ https://www.ncbi.nlm.nih.gov/pubmed/31017387 http://dx.doi.org/10.1021/acschemneuro.9b00105

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