Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development

The molecular basis of Wnt-Frizzled specificity is a central question in developmental biology. Reck, a multi-domain and multi-functional glycosylphosphatidylinositol-anchored protein, specifically enhances beta-catenin signaling by Wnt7a and Wnt7b in cooperation with the 7-transmembrane protein Gpr...

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Detalles Bibliográficos
Autores principales: Cho, Chris, Wang, Yanshu, Smallwood, Philip M, Williams, John, Nathans, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588345/
https://www.ncbi.nlm.nih.gov/pubmed/31225798
http://dx.doi.org/10.7554/eLife.47300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588345/
https://www.ncbi.nlm.nih.gov/pubmed/31225798
http://dx.doi.org/10.7554/eLife.47300

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