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Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity

Developmental enhancers integrate graded concentrations of transcription factors (TFs) to create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) enhancer which drives a sharp expression pattern in the Drosophila blastoderm embryo in response to the transcriptional activator...

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Detalles Bibliográficos
Autores principales:	Park, Jeehae, Estrada, Javier, Johnson, Gemma, Vincent, Ben J, Ricci-Tam, Chiara, Bragdon, Meghan DJ, Shulgina, Yekaterina, Cha, Anna, Wunderlich, Zeba, Gunawardena, Jeremy, DePace, Angela H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588347/ https://www.ncbi.nlm.nih.gov/pubmed/31223115 http://dx.doi.org/10.7554/eLife.41266

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