Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor

Metabotropic glutamate receptors (mGluRs) are class C, synaptic G-protein-coupled receptors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dimers. Despite the existence of a detailed picture of inter-LBD conformational dynamics and structural snapshots o...

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Detalles Bibliográficos
Autores principales: Gutzeit, Vanessa A, Thibado, Jordana, Stor, Daniel Starer, Zhou, Zhou, Blanchard, Scott C, Andersen, Olaf S, Levitz, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588349/
https://www.ncbi.nlm.nih.gov/pubmed/31172948
http://dx.doi.org/10.7554/eLife.45116

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