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Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β(40) (Aβ(40)) by the peptide fragment Aβ(16–22)
Understanding the structural mechanism by which proteins and peptides aggregate is crucial, given the role of fibrillar aggregates in debilitating amyloid diseases and bioinspired materials. Yet, this is a major challenge as the assembly involves multiple heterogeneous and transient intermediates. H...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588359/ https://www.ncbi.nlm.nih.gov/pubmed/31245536 http://dx.doi.org/10.1126/sciadv.aav8216 |