Single-Cell RNA-Seq Reveals TOX as a Key Regulator of CD8(+) T cell Persistence in Chronic Infection

Progenitor-like CD8(+) T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memory precursor cells, including TCF1, but it is unclear whether they adopt distinct programs to adapt to t...

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Detalles Bibliográficos
Autores principales: Yao, Chen, Sun, Hong-Wei, Lacey, Neal E., Ji, Yun, Moseman, E. Ashley, Shih, Han-Yu, Heuston, Elisabeth F., Kirby, Martha, Anderson, Stacie, Cheng, Jun, Khan, Omar, Handon, Robin, Reilley, Julie, Fioravanti, Jessica, Hu, Jinhui, Gossa, Selamawit, Wherry, E. John, Gattinoni, Luca, McGavern, Dorian B., O’Shea, John J., Schwartzberg, Pamela L., Wu, Tuoqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588409/
https://www.ncbi.nlm.nih.gov/pubmed/31209400
http://dx.doi.org/10.1038/s41590-019-0403-4

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