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Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients

Hyaluronan (HA) is associated with innate immune response activation and may be a marker of allograft dysfunction in lung transplant recipients. This was a prospective, single center study comparing levels of bronchioalveolar lavage (BAL) and serum HA and the HA immobilizer LYVE-1 in lung transplant...

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Autores principales: Courtwright, Andrew M., Lamattina, Anthony M., Louis, Pierce H., Trindade, Anil J., Burkett, Patrick, Imani, Jewel, Shrestha, Shikshya, Divo, Miguel, Keller, Steve, Rosas, Ivan O., Goldberg, Hilary J., El-Chemaly, Souheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588572/
https://www.ncbi.nlm.nih.gov/pubmed/31227795
http://dx.doi.org/10.1038/s41598-019-45309-6
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author Courtwright, Andrew M.
Lamattina, Anthony M.
Louis, Pierce H.
Trindade, Anil J.
Burkett, Patrick
Imani, Jewel
Shrestha, Shikshya
Divo, Miguel
Keller, Steve
Rosas, Ivan O.
Goldberg, Hilary J.
El-Chemaly, Souheil
author_facet Courtwright, Andrew M.
Lamattina, Anthony M.
Louis, Pierce H.
Trindade, Anil J.
Burkett, Patrick
Imani, Jewel
Shrestha, Shikshya
Divo, Miguel
Keller, Steve
Rosas, Ivan O.
Goldberg, Hilary J.
El-Chemaly, Souheil
author_sort Courtwright, Andrew M.
collection PubMed
description Hyaluronan (HA) is associated with innate immune response activation and may be a marker of allograft dysfunction in lung transplant recipients. This was a prospective, single center study comparing levels of bronchioalveolar lavage (BAL) and serum HA and the HA immobilizer LYVE-1 in lung transplant recipients with and without acute cellular rejection (ACR). Chronic lung allograft dysfunction (CLAD)-free survival was also evaluated based on HA and LYVE-1 levels. 78 recipients were enrolled with a total of 115 diagnostic biopsies and 1.5 years of median follow-up. Serum HA was correlated with BAL HA (r = 0.25, p = 0.01) and with serum LYVE-1 (r = 0.32, p = 0.002). There was significant variation in HA and LYVE-1 over time, regardless of ACR status. Levels of serum HA (median 74.7 vs 82.7, p = 0.69), BAL HA (median 149.4 vs 134.5, p = 0.39), and LYVE-1 (mean 190.2 vs 183.8, p = 0.72) were not associated with ACR. CLAD-free survival was not different in recipients with any episode of elevated serum HA (HR = 1.5, 95% CI = 0.3–7.7, p = 0.61) or BAL HA (HR = 0.94, 95% CI = 0.2–3.6, p = 0.93). These results did not differ when stratified by bilateral transplant status. In this small cohort, serum HA, BAL HA, and LYVE-1 levels are not associated with ACR or CLAD-free survival in lung transplant recipients.
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spelling pubmed-65885722019-06-28 Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients Courtwright, Andrew M. Lamattina, Anthony M. Louis, Pierce H. Trindade, Anil J. Burkett, Patrick Imani, Jewel Shrestha, Shikshya Divo, Miguel Keller, Steve Rosas, Ivan O. Goldberg, Hilary J. El-Chemaly, Souheil Sci Rep Article Hyaluronan (HA) is associated with innate immune response activation and may be a marker of allograft dysfunction in lung transplant recipients. This was a prospective, single center study comparing levels of bronchioalveolar lavage (BAL) and serum HA and the HA immobilizer LYVE-1 in lung transplant recipients with and without acute cellular rejection (ACR). Chronic lung allograft dysfunction (CLAD)-free survival was also evaluated based on HA and LYVE-1 levels. 78 recipients were enrolled with a total of 115 diagnostic biopsies and 1.5 years of median follow-up. Serum HA was correlated with BAL HA (r = 0.25, p = 0.01) and with serum LYVE-1 (r = 0.32, p = 0.002). There was significant variation in HA and LYVE-1 over time, regardless of ACR status. Levels of serum HA (median 74.7 vs 82.7, p = 0.69), BAL HA (median 149.4 vs 134.5, p = 0.39), and LYVE-1 (mean 190.2 vs 183.8, p = 0.72) were not associated with ACR. CLAD-free survival was not different in recipients with any episode of elevated serum HA (HR = 1.5, 95% CI = 0.3–7.7, p = 0.61) or BAL HA (HR = 0.94, 95% CI = 0.2–3.6, p = 0.93). These results did not differ when stratified by bilateral transplant status. In this small cohort, serum HA, BAL HA, and LYVE-1 levels are not associated with ACR or CLAD-free survival in lung transplant recipients. Nature Publishing Group UK 2019-06-21 /pmc/articles/PMC6588572/ /pubmed/31227795 http://dx.doi.org/10.1038/s41598-019-45309-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Courtwright, Andrew M.
Lamattina, Anthony M.
Louis, Pierce H.
Trindade, Anil J.
Burkett, Patrick
Imani, Jewel
Shrestha, Shikshya
Divo, Miguel
Keller, Steve
Rosas, Ivan O.
Goldberg, Hilary J.
El-Chemaly, Souheil
Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title_full Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title_fullStr Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title_full_unstemmed Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title_short Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients
title_sort hyaluronan and lyve-1 and allograft function in lung transplantation recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588572/
https://www.ncbi.nlm.nih.gov/pubmed/31227795
http://dx.doi.org/10.1038/s41598-019-45309-6
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