IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer. We find that genetic ablation or therapeutic inactivatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Eissmann, Moritz F., Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh R., Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas D., Hibbs, Margaret L., Boussioutas, Alex, Grimbaldeston, Michele A., Buchert, Michael, O’Donoghue, Robert J. J., Masson, Frederick, Ernst, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588585/
https://www.ncbi.nlm.nih.gov/pubmed/31227713
http://dx.doi.org/10.1038/s41467-019-10676-1

Ejemplares similares

Ejemplares similares