NTHL1 biallelic mutations seldom cause colorectal cancer, serrated polyposis or a multi-tumor phenotype, in absence of colorectal adenomas

The cancer-predisposing syndrome caused by biallelic mutations in NTHL1 may not be a solely colorectal cancer (CRC) and polyposis syndrome but rather a multi-tumor recessive disease. The presence of ≤10 adenomas in several mutation carriers suggests a possible causal role of NTHL1 in hereditary or e...

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Detalles Bibliográficos
Autores principales: Belhadj, Sami, Quintana, Isabel, Mur, Pilar, Munoz-Torres, Pau M., Alonso, M. Henar, Navarro, Matilde, Terradas, Mariona, Piñol, Virginia, Brunet, Joan, Moreno, Victor, Lázaro, Conxi, Capellá, Gabriel, Valle, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588610/
https://www.ncbi.nlm.nih.gov/pubmed/31227763
http://dx.doi.org/10.1038/s41598-019-45281-1

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