High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Genomic screening of cancer patients for predisposing variants is traditionally based on age at onset, family history and type of cancer. Whereas the clinical guidelines have proven efficient in identifying families exhibiting classical attributes of hereditary cancer, the frequency of patients with...

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Detalles Bibliográficos
Autores principales: Bertelsen, Birgitte, Tuxen, Ida Viller, Yde, Christina Westmose, Gabrielaite, Migle, Torp, Mathias Husted, Kinalis, Savvas, Oestrup, Olga, Rohrberg, Kristoffer, Spangaard, Iben, Santoni-Rugiu, Eric, Wadt, Karin, Mau-Sorensen, Morten, Lassen, Ulrik, Nielsen, Finn Cilius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588611/
https://www.ncbi.nlm.nih.gov/pubmed/31263571
http://dx.doi.org/10.1038/s41525-019-0087-6

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