Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling

The unfolded protein response (UPR) acts through its downstream branches, PERK-eIF2α signaling, IRE1α-XBP1 signaling and ATF6 signaling. In the intestine, activation of the UPR through the kinase PERK results in differentiation of intestinal epithelial stem cells and colon cancer stem cells, whereas...

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Detalles Bibliográficos
Autores principales: Spaan, Claudia N., Smit, Wouter L., van Lidth de Jeude, Jooske F., Meijer, Bartolomeus J., Muncan, Vanesa, van den Brink, Gijs R., Heijmans, Jarom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588629/
https://www.ncbi.nlm.nih.gov/pubmed/31227689
http://dx.doi.org/10.1038/s41419-019-1729-4

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