Use of levosimendan in acute and advanced heart failure: short review on available real-world data

Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from...

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Autores principales: Pashkovetsky, Eugene, Gupta, Chhaya Aggarwal, Aronow, Wilbert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588712/
https://www.ncbi.nlm.nih.gov/pubmed/31354283
http://dx.doi.org/10.2147/TCRM.S188761
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author Pashkovetsky, Eugene
Gupta, Chhaya Aggarwal
Aronow, Wilbert S
author_facet Pashkovetsky, Eugene
Gupta, Chhaya Aggarwal
Aronow, Wilbert S
author_sort Pashkovetsky, Eugene
collection PubMed
description Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug.
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spelling pubmed-65887122019-07-26 Use of levosimendan in acute and advanced heart failure: short review on available real-world data Pashkovetsky, Eugene Gupta, Chhaya Aggarwal Aronow, Wilbert S Ther Clin Risk Manag Review Published data have shown potential advantages of levosimendan in the management of acute decompensated heart failure and advanced heart failure when standard medical therapies threaten hemodynamics and organ perfusion are unable to alleviate clinical symptoms. Levosimendan distinguishes itself from other catecholaminergic inotropes by its three mechanisms of action: positive inotropy, vasodilation, and cardioprotection. In addition, its pharmacokinetics allow for a longer duration of action from the metabolite OR1896 allowing for further cardiovascular therapeutic effects for several days, even after discontinuation of the parent drug. Dove 2019-06-17 /pmc/articles/PMC6588712/ /pubmed/31354283 http://dx.doi.org/10.2147/TCRM.S188761 Text en © 2019 Pashkovetsky et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Pashkovetsky, Eugene
Gupta, Chhaya Aggarwal
Aronow, Wilbert S
Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title_full Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title_fullStr Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title_full_unstemmed Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title_short Use of levosimendan in acute and advanced heart failure: short review on available real-world data
title_sort use of levosimendan in acute and advanced heart failure: short review on available real-world data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588712/
https://www.ncbi.nlm.nih.gov/pubmed/31354283
http://dx.doi.org/10.2147/TCRM.S188761
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