DEPTOR induces a partial epithelial-to-mesenchymal transition and metastasis via autocrine TGFβ1 signaling and is associated with poor prognosis in hepatocellular carcinoma

BACKGROUND: DEPTOR is an endogenous inhibitor of mTORC1 and mTORC2 that plays a vital role in the progression of human malignances. However, the biological function of DEPTOR in HCC metastasis and the underlying molecular mechanisms are still unclear. METHODS: Western blot analysis and immunohistoch...

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Detalles Bibliográficos
Autores principales: Chen, Jin, Zhu, Haidan, Liu, Qiumeng, Ning, Deng, Zhang, Zhaoqi, Zhang, Long, Mo, Jie, Du, Pengcheng, Liu, Xu, Song, Shasha, Fan, Yawei, Liang, Huifang, Liu, Jikui, Zhang, Bixiang, Chen, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588925/
https://www.ncbi.nlm.nih.gov/pubmed/31228948
http://dx.doi.org/10.1186/s13046-019-1220-1

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