XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity

The human MT(1)(1) and MT(2)(2) melatonin receptors are G protein-coupled receptors (GPCRs) involved in the regulation of circadian rhythm and sleep patterns(3). Drug development efforts target both receptors for treatment of insomnia, circadian rhythm and mood disorders, and cancer(3), while MT(2)...

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Detalles Bibliográficos
Autores principales: Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, Shuming, Olsen, Reid H.J., Tribo, Alexandra R., Zaare, Sahba, Zhu, Lan, Zatsepin, Nadia A., Weierstall, Uwe, Yous, Saïd, Stevens, Raymond C., Liu, Wei, Roth, Bryan L., Katritch, Vsevolod, Cherezov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589158/
https://www.ncbi.nlm.nih.gov/pubmed/31019305
http://dx.doi.org/10.1038/s41586-019-1144-0

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