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Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

BACKGROUND: Type I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown. METHODS: Tumor tissues and CTLs of human colorectal cancer p...

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Detalles Bibliográficos
Autores principales:	Lu, Chunwan, Klement, John D., Ibrahim, Mohammed L., Xiao, Wei, Redd, Priscilla S., Nayak-Kapoor, Asha, Zhou, Gang, Liu, Kebin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589175/ https://www.ncbi.nlm.nih.gov/pubmed/31228946 http://dx.doi.org/10.1186/s40425-019-0635-8

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