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Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders

INTRODUCTION/OBJECTIVE: In the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopu...

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Autores principales: Bellan, Mattia, Giubertoni, Ailia, Piccinino, Cristina, Dimagli, Arnaldo, Grimoldi, Federico, Sguazzotti, Maurizio, Burlone, Michela Emma, Smirne, Carlo, Sola, Daniele, Marino, Paolo, Pirisi, Mario, Sainaghi, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589198/
https://www.ncbi.nlm.nih.gov/pubmed/31275447
http://dx.doi.org/10.1155/2019/4981982
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author Bellan, Mattia
Giubertoni, Ailia
Piccinino, Cristina
Dimagli, Arnaldo
Grimoldi, Federico
Sguazzotti, Maurizio
Burlone, Michela Emma
Smirne, Carlo
Sola, Daniele
Marino, Paolo
Pirisi, Mario
Sainaghi, Pier Paolo
author_facet Bellan, Mattia
Giubertoni, Ailia
Piccinino, Cristina
Dimagli, Arnaldo
Grimoldi, Federico
Sguazzotti, Maurizio
Burlone, Michela Emma
Smirne, Carlo
Sola, Daniele
Marino, Paolo
Pirisi, Mario
Sainaghi, Pier Paolo
author_sort Bellan, Mattia
collection PubMed
description INTRODUCTION/OBJECTIVE: In the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopulmonary impairment in these patients. METHODS: The study population included N = 141 patients with CTD and N = 59 patients affected by pulmonary hypertension of other etiologies, all referred to the Pulmonary Hypertension Clinic of the Cardiology Division of an Academic Hospital in Northern Italy for evaluation (including right catheterization). Clinical, instrumental, and laboratory data were collected and related to RDW and other full blood count indexes. RESULTS: Twenty out of 141 CTD patients (14%) received a diagnosis of PAH. In comparison to those without PAH, CTD patients with PAH displayed a larger RDW (14.9% (13.5-17.2) vs. 13.8% (13.1-15.0); p = 0.02) and a lower platelet count (205 (177‐240) × 10(9)/l vs. 244 (197.5‐304.2) × 10(9)/l; p = 0.005). Moreover, with respect to CTD patients without PAH, RDW was significantly larger also in PH of other etiologies. In contrast, the platelet count was significantly lower only in CTD-related PAH, with a value > 276 × 10(9)/l being 100% sensitive in ruling out PAH. Finally, RDW, but not the platelet count, was related directly to systolic pulmonary arterial pressure (r = 0.381; p = 0.0008) and right ventricle diameter (r = 0.283; p = 0.015) and inversely to diffusing capacity of the lung for carbon monoxide (r = −0.325; p = 0.014). CONCLUSION: RDW is a promising candidate biomarker for the screening and the prognostic stratification of PAH in CTD patients.
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spelling pubmed-65891982019-07-04 Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders Bellan, Mattia Giubertoni, Ailia Piccinino, Cristina Dimagli, Arnaldo Grimoldi, Federico Sguazzotti, Maurizio Burlone, Michela Emma Smirne, Carlo Sola, Daniele Marino, Paolo Pirisi, Mario Sainaghi, Pier Paolo Dis Markers Research Article INTRODUCTION/OBJECTIVE: In the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopulmonary impairment in these patients. METHODS: The study population included N = 141 patients with CTD and N = 59 patients affected by pulmonary hypertension of other etiologies, all referred to the Pulmonary Hypertension Clinic of the Cardiology Division of an Academic Hospital in Northern Italy for evaluation (including right catheterization). Clinical, instrumental, and laboratory data were collected and related to RDW and other full blood count indexes. RESULTS: Twenty out of 141 CTD patients (14%) received a diagnosis of PAH. In comparison to those without PAH, CTD patients with PAH displayed a larger RDW (14.9% (13.5-17.2) vs. 13.8% (13.1-15.0); p = 0.02) and a lower platelet count (205 (177‐240) × 10(9)/l vs. 244 (197.5‐304.2) × 10(9)/l; p = 0.005). Moreover, with respect to CTD patients without PAH, RDW was significantly larger also in PH of other etiologies. In contrast, the platelet count was significantly lower only in CTD-related PAH, with a value > 276 × 10(9)/l being 100% sensitive in ruling out PAH. Finally, RDW, but not the platelet count, was related directly to systolic pulmonary arterial pressure (r = 0.381; p = 0.0008) and right ventricle diameter (r = 0.283; p = 0.015) and inversely to diffusing capacity of the lung for carbon monoxide (r = −0.325; p = 0.014). CONCLUSION: RDW is a promising candidate biomarker for the screening and the prognostic stratification of PAH in CTD patients. Hindawi 2019-06-02 /pmc/articles/PMC6589198/ /pubmed/31275447 http://dx.doi.org/10.1155/2019/4981982 Text en Copyright © 2019 Mattia Bellan et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bellan, Mattia
Giubertoni, Ailia
Piccinino, Cristina
Dimagli, Arnaldo
Grimoldi, Federico
Sguazzotti, Maurizio
Burlone, Michela Emma
Smirne, Carlo
Sola, Daniele
Marino, Paolo
Pirisi, Mario
Sainaghi, Pier Paolo
Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title_full Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title_fullStr Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title_full_unstemmed Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title_short Red Cell Distribution Width and Platelet Count as Biomarkers of Pulmonary Arterial Hypertension in Patients with Connective Tissue Disorders
title_sort red cell distribution width and platelet count as biomarkers of pulmonary arterial hypertension in patients with connective tissue disorders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589198/
https://www.ncbi.nlm.nih.gov/pubmed/31275447
http://dx.doi.org/10.1155/2019/4981982
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