Cargando…

P2Y6 Receptor-Mediated Spinal Microglial Activation in Neuropathic Pain

OBJECTIVE: To explore the role of purine family member P2Y6 receptors in regulating neuropathic pain (NP) via neuroinflammation in the spinal cord. METHODS: Chronic constriction injury of the sciatic nerve (CCI) of NP was classic in setting up models on Sprague-Dawley (SD) rats. Experiments were per...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bian, Jiang, Zhang, Ying, Liu, Yan, Li, Qun, Tang, Hai-bin, Liu, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589212/ https://www.ncbi.nlm.nih.gov/pubmed/31281556 http://dx.doi.org/10.1155/2019/2612534

Ejemplares similares

p38 MAPK, microglial signaling, and neuropathic pain
por: Ji, Ru-Rong, et al.
Publicado: (2007)

Modification of neuropathic pain sensation through microglial ATP receptors
por: Inoue, Kazuhide, et al.
Publicado: (2007)

Neuronal and microglial mechanisms of neuropathic pain
por: Zhuo, Min, et al.
Publicado: (2011)

TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States
por: Batti, Laura, et al.
Publicado: (2016)

The temporal and spatial signature of microglial transcriptome in neuropathic pain
por: Liu, Zeyuan, et al.
Publicado: (2023)

Suppression of microglial Ccl2 reduces neuropathic pain associated with chronic spinal compression
por: Li, Quan, et al.
Publicado: (2023)

Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord
por: Zhang, Ting-Ting, et al.
Publicado: (2018)

Effects of norepinephrine on microglial neuroinflammation and neuropathic pain
por: Zou, He‐Lin, et al.
Publicado: (2021)

Spinal microglial β‐endorphin signaling mediates IL‐10 and exenatide‐induced inhibition of synaptic plasticity in neuropathic pain
por: Ma, Le, et al.
Publicado: (2021)

P2Y6 Receptor-Mediated Microglial Phagocytosis in Radiation-Induced Brain Injury
por: Xu, Yongteng, et al.
Publicado: (2015)

Loss of spinal substance P pain transmission under the condition of LPA(1 )receptor-mediated neuropathic pain
por: Inoue, Makoto, et al.
Publicado: (2006)

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
por: Toth, Cory C, et al.
Publicado: (2010)

Effects of 1,8-cineole on neuropathic pain mediated by P2X2 receptor in the spinal cord dorsal horn
por: Zheng, Xiao-bo, et al.
Publicado: (2019)

Role of Dehydrocorybulbine in Neuropathic Pain After Spinal Cord Injury Mediated by P2X4 Receptor
por: Wang, Zhongwei, et al.
Publicado: (2019)

Regulation of neuropathic pain by microglial Orai1 channels
por: Tsujikawa, Shogo, et al.
Publicado: (2023)

Role of spinal P2Y(6) and P2Y(11) receptors in neuropathic pain in rats: possible involvement of glial cells
por: Barragán-Iglesias, Paulino, et al.
Publicado: (2014)

Carbon Monoxide Reduces Neuropathic Pain and Spinal Microglial Activation by Inhibiting Nitric Oxide Synthesis in Mice
por: Hervera, Arnau, et al.
Publicado: (2012)

Erratum to: Role of Dehydrocorybulbine in Neuropathic Pain After Spinal Cord Injury Mediated by P2X4 Receptor
por: Wang, Zhongwei, et al.
Publicado: (2019)

NFAT1 Orchestrates Spinal Microglial Transcription and Promotes Microglial Proliferation via c‐MYC Contributing to Nerve Injury‐Induced Neuropathic Pain
por: Jiang, Bao‐Chun, et al.
Publicado: (2022)

Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury
por: Kiguchi, Norikazu, et al.
Publicado: (2018)

Microglial P2X4 receptors are essential for spinal neurons hyperexcitability and tactile allodynia in male and female neuropathic mice
por: Gilabert, Damien, et al.
Publicado: (2023)

Minocycline treatment inhibits microglial activation and alters spinal levels of endocannabinoids in a rat model of neuropathic pain
por: Guasti, Leonardo, et al.
Publicado: (2009)

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection
por: Martini, Alessandra Cadete, et al.
Publicado: (2016)

Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain
por: Mika, Joanna, et al.
Publicado: (2014)

The Role of Bone Morphogenetic Protein 4 in Microglial Polarization in the Process of Neuropathic Pain
por: Liu, Changqing, et al.
Publicado: (2022)

Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats
por: Kuthati, Yaswanth, et al.
Publicado: (2019)

Age-Related Differences in Neuropathic Pain Behavior and Spinal Microglial Activity after L5 Spinal Nerve Ligation in Male Rats
por: Zeinali, Hossein, et al.
Publicado: (2016)

Activation of spinal dorsal horn P2Y(13) receptors can promote the expression of IL-1β and IL-6 in rats with diabetic neuropathic pain
por: Zhou, Rui, et al.
Publicado: (2018)

Duloxetine Inhibits Microglial P2X4 Receptor Function and Alleviates Neuropathic Pain after Peripheral Nerve Injury
por: Yamashita, Tomohiro, et al.
Publicado: (2016)

Minocycline Effects on IL-6 Concentration in Macrophage and Microglial Cells in a Rat Model of Neuropathic Pain
por: Moini-Zanjani, Taraneh, et al.
Publicado: (2016)

Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain
por: Popiolek-Barczyk, Katarzyna, et al.
Publicado: (2016)

Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats
por: Xu, Xueru, et al.
Publicado: (2019)

The Constitutive Activity of Spinal 5-HT(6) Receptors Contributes to Diabetic Neuropathic Pain in Rats
por: Mokhtar, Nazarine, et al.
Publicado: (2023)

Suppression of Superficial Microglial Activation by Spinal Cord Stimulation Attenuates Neuropathic Pain Following Sciatic Nerve Injury in Rats
por: Shinoda, Masamichi, et al.
Publicado: (2020)

Pellino1 regulates neuropathic pain as well as microglial activation through the regulation of MAPK/NF-κB signaling in the spinal cord
por: Wang, Lijuan, et al.
Publicado: (2020)

PINK1 mediates spinal cord mitophagy in neuropathic pain
por: Yi, Min-Hee, et al.
Publicado: (2019)

The microglial P2Y(6) receptor mediates neuronal loss and memory deficits in neurodegeneration
por: Puigdellívol, Mar, et al.
Publicado: (2021)

Intrathecal lidocaine pretreatment attenuates immediate neuropathic pain by modulating Nav(1.3 )expression and decreasing spinal microglial activation
por: Cheng, Kuang-I, et al.
Publicado: (2011)

Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases
por: Kuboyama, Kazuya, et al.
Publicado: (2011)

Microglial TNFα Induces COX2 and PGI2 Synthase Expression in Spinal Endothelial Cells during Neuropathic Pain
por: Kanda, Hirosato, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pi01g5tgrlodtg4vaemtnop77c