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Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis
OBJECTIVE: To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. METHODS: Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589214/ https://www.ncbi.nlm.nih.gov/pubmed/31275450 http://dx.doi.org/10.1155/2019/6710352 |
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author | Liu, Zhenhua Shi, Hongtai |
author_facet | Liu, Zhenhua Shi, Hongtai |
author_sort | Liu, Zhenhua |
collection | PubMed |
description | OBJECTIVE: To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. METHODS: Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the quality of literature collected was assessed based on evaluation criteria. The heterogeneity, sensitivity, and specificity were detected using the StataSE12.0 software, and the correlation between SCC-Ag and cervical cancer prognosis as the effect variables was assessed using the hazard ratio (HR) and 95% confidence interval (CI). Moreover, the forest map and funnel plot were drawn. RESULTS: A total of 17 articles meeting the inclusion criteria were selected. The high expression of SCC-Ag was significantly correlated with the poor prognosis of cervical cancer (HR = 2.22, 95% CI = 1.38 − 3.57, P = 0.002). The disease-free survival (DFS) was higher in low SCC-Ag expression patients than in high SCC-Ag expression patients (HR = 2.17, 95% CI = 1.84 − 2.57, P < 0.001). The progression-free survival (PFS) was inferior in patients with a high SCC-Ag expression (HR = 2.70, 95% CI = 1.11 − 6.53, P = 0.028). CONCLUSION: SCC-Ag is an important prognostic factor for cervical cancer, and its high expression is significantly correlated with a poor prognosis of the disease. |
format | Online Article Text |
id | pubmed-6589214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65892142019-07-04 Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis Liu, Zhenhua Shi, Hongtai Dis Markers Research Article OBJECTIVE: To systematically evaluate the significance of squamous cell carcinoma antigen (SCC-Ag) in the prognosis of cervical cancer. METHODS: Literature from Pubmed, Embase, and Cochrane Library was retrieved to collect all English literature on the correlation between SCC-Ag and cervical cancer prognosis, and the quality of literature collected was assessed based on evaluation criteria. The heterogeneity, sensitivity, and specificity were detected using the StataSE12.0 software, and the correlation between SCC-Ag and cervical cancer prognosis as the effect variables was assessed using the hazard ratio (HR) and 95% confidence interval (CI). Moreover, the forest map and funnel plot were drawn. RESULTS: A total of 17 articles meeting the inclusion criteria were selected. The high expression of SCC-Ag was significantly correlated with the poor prognosis of cervical cancer (HR = 2.22, 95% CI = 1.38 − 3.57, P = 0.002). The disease-free survival (DFS) was higher in low SCC-Ag expression patients than in high SCC-Ag expression patients (HR = 2.17, 95% CI = 1.84 − 2.57, P < 0.001). The progression-free survival (PFS) was inferior in patients with a high SCC-Ag expression (HR = 2.70, 95% CI = 1.11 − 6.53, P = 0.028). CONCLUSION: SCC-Ag is an important prognostic factor for cervical cancer, and its high expression is significantly correlated with a poor prognosis of the disease. Hindawi 2019-06-02 /pmc/articles/PMC6589214/ /pubmed/31275450 http://dx.doi.org/10.1155/2019/6710352 Text en Copyright © 2019 Zhenhua Liu and Hongtai Shi. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Liu, Zhenhua Shi, Hongtai Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title | Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title_full | Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title_fullStr | Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title_full_unstemmed | Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title_short | Prognostic Role of Squamous Cell Carcinoma Antigen in Cervical Cancer: A Meta-analysis |
title_sort | prognostic role of squamous cell carcinoma antigen in cervical cancer: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589214/ https://www.ncbi.nlm.nih.gov/pubmed/31275450 http://dx.doi.org/10.1155/2019/6710352 |
work_keys_str_mv | AT liuzhenhua prognosticroleofsquamouscellcarcinomaantigenincervicalcancerametaanalysis AT shihongtai prognosticroleofsquamouscellcarcinomaantigenincervicalcancerametaanalysis |