Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant

Ankyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesi...

Descripción completa

Detalles Bibliográficos
Autores principales: Husnain, Muhammad, Wang, Trent, Valdes, Maikel, Hoffman, James, Lekakis, Lazaros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589226/
https://www.ncbi.nlm.nih.gov/pubmed/31281687
http://dx.doi.org/10.1155/2019/9357572
_version_ 1783429357801308160
author Husnain, Muhammad
Wang, Trent
Valdes, Maikel
Hoffman, James
Lekakis, Lazaros
author_facet Husnain, Muhammad
Wang, Trent
Valdes, Maikel
Hoffman, James
Lekakis, Lazaros
author_sort Husnain, Muhammad
collection PubMed
description Ankyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesis on bone marrow evaluation. ANKRD26 mutation has been previously associated with myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. We report the first case of multiple myeloma in a patient with ANKRD26 related thrombocytopenia. The patient was successfully treated with contemporary combination therapy followed by melphalan-conditioned autologous stem cell transplant for his multiple myeloma despite preexisting thrombocytopenia.
format Online
Article
Text
id pubmed-6589226
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-65892262019-07-07 Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant Husnain, Muhammad Wang, Trent Valdes, Maikel Hoffman, James Lekakis, Lazaros Case Rep Hematol Case Report Ankyrin repeat domain-containing protein 26- (ANKRD26-) related thrombocytopenia is a rare, autosomal dominant condition caused by ANKRD26 gene mutation. ANKRD26-related thrombocytopenia is characterized by moderate thrombocytopenia with minimal bleeding, normal platelet size, and dysmegakaryopoiesis on bone marrow evaluation. ANKRD26 mutation has been previously associated with myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndrome, and chronic myeloid leukemia. We report the first case of multiple myeloma in a patient with ANKRD26 related thrombocytopenia. The patient was successfully treated with contemporary combination therapy followed by melphalan-conditioned autologous stem cell transplant for his multiple myeloma despite preexisting thrombocytopenia. Hindawi 2019-06-02 /pmc/articles/PMC6589226/ /pubmed/31281687 http://dx.doi.org/10.1155/2019/9357572 Text en Copyright © 2019 Muhammad Husnain et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Husnain, Muhammad
Wang, Trent
Valdes, Maikel
Hoffman, James
Lekakis, Lazaros
Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title_full Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title_fullStr Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title_full_unstemmed Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title_short Multiple Myeloma in a Patient with ANKRD26-Related Thrombocytopenia Successfully Treated with Combination Therapy and Autologous Stem Cell Transplant
title_sort multiple myeloma in a patient with ankrd26-related thrombocytopenia successfully treated with combination therapy and autologous stem cell transplant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589226/
https://www.ncbi.nlm.nih.gov/pubmed/31281687
http://dx.doi.org/10.1155/2019/9357572
work_keys_str_mv AT husnainmuhammad multiplemyelomainapatientwithankrd26relatedthrombocytopeniasuccessfullytreatedwithcombinationtherapyandautologousstemcelltransplant
AT wangtrent multiplemyelomainapatientwithankrd26relatedthrombocytopeniasuccessfullytreatedwithcombinationtherapyandautologousstemcelltransplant
AT valdesmaikel multiplemyelomainapatientwithankrd26relatedthrombocytopeniasuccessfullytreatedwithcombinationtherapyandautologousstemcelltransplant
AT hoffmanjames multiplemyelomainapatientwithankrd26relatedthrombocytopeniasuccessfullytreatedwithcombinationtherapyandautologousstemcelltransplant
AT lekakislazaros multiplemyelomainapatientwithankrd26relatedthrombocytopeniasuccessfullytreatedwithcombinationtherapyandautologousstemcelltransplant

Ejemplares similares