Cargando…
Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs
Inflammatory bowel disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. Since inflammatory bowel disease-associated spondyloarthritis has been associated with a significant diagnostic d...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589275/ https://www.ncbi.nlm.nih.gov/pubmed/31276001 http://dx.doi.org/10.1155/2019/8630871 |
_version_ | 1783429369353469952 |
---|---|
author | Benfaremo, Devis Luchetti, Michele Maria Gabrielli, Armando |
author_facet | Benfaremo, Devis Luchetti, Michele Maria Gabrielli, Armando |
author_sort | Benfaremo, Devis |
collection | PubMed |
description | Inflammatory bowel disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. Since inflammatory bowel disease-associated spondyloarthritis has been associated with a significant diagnostic delay, which may lead to poor quality of life and progression of joint damage, efforts to discover new reliable and noninvasive diagnostic biomarkers have been made. We reviewed the state of the art of biomarker research in inflammatory bowel disease-associated spondyloarthritis, showing that to date it has been largely unsatisfactory. Only a few of the biomarkers that have been investigated are likely to enter the clinical practice upon further validation in independent cohorts. The research of new and innovative biomarkers for inflammatory bowel disease-associated spondyloarthritis is warranted. |
format | Online Article Text |
id | pubmed-6589275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65892752019-07-04 Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs Benfaremo, Devis Luchetti, Michele Maria Gabrielli, Armando J Immunol Res Review Article Inflammatory bowel disease-associated spondyloarthritis is a systemic disease characterized by the chronic inflammation of both the gastrointestinal tract and the musculoskeletal system. Since inflammatory bowel disease-associated spondyloarthritis has been associated with a significant diagnostic delay, which may lead to poor quality of life and progression of joint damage, efforts to discover new reliable and noninvasive diagnostic biomarkers have been made. We reviewed the state of the art of biomarker research in inflammatory bowel disease-associated spondyloarthritis, showing that to date it has been largely unsatisfactory. Only a few of the biomarkers that have been investigated are likely to enter the clinical practice upon further validation in independent cohorts. The research of new and innovative biomarkers for inflammatory bowel disease-associated spondyloarthritis is warranted. Hindawi 2019-05-30 /pmc/articles/PMC6589275/ /pubmed/31276001 http://dx.doi.org/10.1155/2019/8630871 Text en Copyright © 2019 Devis Benfaremo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Benfaremo, Devis Luchetti, Michele Maria Gabrielli, Armando Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title | Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title_full | Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title_fullStr | Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title_full_unstemmed | Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title_short | Biomarkers in Inflammatory Bowel Disease-Associated Spondyloarthritis: State of the Art and Unmet Needs |
title_sort | biomarkers in inflammatory bowel disease-associated spondyloarthritis: state of the art and unmet needs |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589275/ https://www.ncbi.nlm.nih.gov/pubmed/31276001 http://dx.doi.org/10.1155/2019/8630871 |
work_keys_str_mv | AT benfaremodevis biomarkersininflammatoryboweldiseaseassociatedspondyloarthritisstateoftheartandunmetneeds AT luchettimichelemaria biomarkersininflammatoryboweldiseaseassociatedspondyloarthritisstateoftheartandunmetneeds AT gabrielliarmando biomarkersininflammatoryboweldiseaseassociatedspondyloarthritisstateoftheartandunmetneeds |