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Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics

Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the unifo...

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Detalles Bibliográficos
Autores principales:	Ly, Thu, Pappas, Christopher T., Johnson, Dylan, Schlecht, William, Colpan, Mert, Galkin, Vitold E., Gregorio, Carol C., Dong, Wen-Ji, Kostyukova, Alla S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589558/ https://www.ncbi.nlm.nih.gov/pubmed/30462572 http://dx.doi.org/10.1091/mbc.E18-06-0406

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