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Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission

Mitochondria exist in an equilibrium between fragmented and fused states that shifts heavily toward fission in response to cellular damage. Nuclear-to-cytoplasmic cyclin C relocalization is essential for dynamin-related protein 1 (Drp1)–dependent mitochondrial fission in response to oxidative stress...

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Detalles Bibliográficos
Autores principales:	Ganesan, Vidyaramanan, Willis, Stephen D., Chang, Kai-Ti, Beluch, Samuel, Cooper, Katrina F., Strich, Randy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Brief Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589575/ https://www.ncbi.nlm.nih.gov/pubmed/30516433 http://dx.doi.org/10.1091/mbc.E18-07-0463

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