Cargando…

Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation

Junctional adhesion molecule-A (JAM-A), an epithelial tight junction protein, plays an important role in regulating intestinal permeability through association with a scaffold signaling complex containing ZO-2, Afadin, and the small GTPase Rap2. Under inflammatory conditions, we report that the cyto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Shuling, Weight, Caroline M., Luissint, Anny-Claude, Hilgarth, Roland S., Brazil, Jennifer C., Ettel, Mark, Nusrat, Asma, Parkos, Charles A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589701/ https://www.ncbi.nlm.nih.gov/pubmed/30625033 http://dx.doi.org/10.1091/mbc.E18-08-0531

Ejemplares similares

Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
por: Reed, Michelle, et al.
Publicado: (2019)

Epithelial JAM-A is fundamental for intestinal wound repair in vivo
por: Fan, Shuling, et al.
Publicado: (2022)

JAM-A signals through the Hippo pathway to regulate intestinal epithelial proliferation
por: Fan, Shuling, et al.
Publicado: (2022)

Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function
por: Raya-Sandino, Arturo, et al.
Publicado: (2023)

Protein kinase CK2 is a critical regulator of epithelial homeostasis in chronic intestinal inflammation
por: Koch, Stefan, et al.
Publicado: (2012)

Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2
por: Raya-Sandino, Arturo, et al.
Publicado: (2021)

Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface
por: Monteiro, Ana C., et al.
Publicado: (2014)

Neutrophil Interactions with Epithelial Expressed ICAM-1 Enhances Intestinal Mucosal Wound Healing
por: Sumagin, R, et al.
Publicado: (2016)

Intracellular Desmoglein-2 cleavage sensitizes epithelial cells to apoptosis in response to pro-inflammatory cytokines
por: Yulis, Mark, et al.
Publicado: (2018)

Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration
por: Flemming, Sven, et al.
Publicado: (2020)

Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo.
por: Azcutia, Veronica, et al.
Publicado: (2020)

Transmigrated neutrophils in the intestinal lumen engage ICAM 1 to regulate the epithelial barrier and neutrophil recruitment
por: Sumagin, Ronen, et al.
Publicado: (2013)

JAM-A regulates permeability and inflammation in the intestine in vivo
por: Laukoetter, Mike G., et al.
Publicado: (2007)

Distinct stimulus-dependent neutrophil dynamics revealed by real-time imaging of intestinal mucosa after acute injury
por: Azcutia, Veronica, et al.
Publicado: (2022)

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function
por: Monteiro, Ana C., et al.
Publicado: (2013)

JAM-L–mediated leukocyte adhesion to endothelial cells is regulated in cis by α4β1 integrin activation
por: Luissint, Anny-Claude, et al.
Publicado: (2008)

IFN-γ and TNF-α induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling
por: Capaldo, Christopher T., et al.
Publicado: (2012)

Intestinal epithelial BLT1 promotes mucosal repair
por: Hayashi, Shusaku, et al.
Publicado: (2022)

Neutrophil-derived JAML Inhibits Repair of Intestinal Epithelial Injury During Acute Inflammation
por: Weber, Dominique A., et al.
Publicado: (2014)

Sialylation regulates neutrophil transepithelial migration, CD11b/CD18 activation, and intestinal mucosal inflammatory function
por: Azcutia, Veronica, et al.
Publicado: (2023)

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation
por: Luissint, Anny-Claude, et al.
Publicado: (2012)

Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation
por: Brazil, Jennifer C., et al.
Publicado: (2021)

TNFα promotes mucosal wound repair through enhanced Platelet Activating Factor Receptor signaling in the epithelium
por: Birkl, Dorothee, et al.
Publicado: (2019)

Activation of PKCβII by PMA Facilitates Enhanced Epithelial Wound Repair through Increased Cell Spreading and Migration
por: Sumagin, Ronen, et al.
Publicado: (2013)

Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins
por: Capaldo, Christopher T., et al.
Publicado: (2014)

Geometric constraints during epithelial jamming
por: Atia, Lior, et al.
Publicado: (2018)

Maresin-2 promotes mucosal repair and has therapeutic potential when encapsulated in thermostable nanoparticles
por: Miranda, Jael, et al.
Publicado: (2023)

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling
por: Kolegraff, Keli, et al.
Publicado: (2011)

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility
por: Ivanov, Andrei I, et al.
Publicado: (2009)

Microtubules regulate disassembly of epithelial apical junctions
por: Ivanov, Andrei I, et al.
Publicado: (2006)

A Unique Role for Nonmuscle Myosin Heavy Chain IIA in Regulation of Epithelial Apical Junctions
por: Ivanov, Andrei I., et al.
Publicado: (2007)

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier
por: Kamekura, Ryuta, et al.
Publicado: (2015)

Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity
por: Yu, Linda Chia-Hui
Publicado: (2012)

Junctional Adhesion Molecules (JAMs): The JAM-Integrin Connection
por: Kummer, Daniel, et al.
Publicado: (2018)

Clipping EpCAM to release Claudin-7 for the greater good of the epithelial barrier
por: Varadarajan, Saranyaraajan, et al.
Publicado: (2022)

Ligand-Induced Tyrosine Phosphorylation of Cysteinyl Leukotriene Receptor 1 Triggers Internalization and Signaling in Intestinal Epithelial Cells
por: Parhamifar, Ladan, et al.
Publicado: (2010)

The Role of Tricellulin in Epithelial Jamming and Unjamming via Segmentation of Tricellular Junctions
por: Lohmann, Sophie, et al.
Publicado: (2020)

IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ
por: Nava, Porfirio, et al.
Publicado: (2014)

Junkyard Jam Band
por: Nelson, David
Publicado: (2015)

Jamming transitions in cancer
por: Oswald, Linda, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_boq7sld5vdf7ncf59qu3tmvpu3