FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB

Rho GTPases control both the actin cytoskeleton and adherens junction stability and are recognized as essential regulators of endothelial barrier function. They act as molecular switches and are primarily regulated by the exchange of GDP and GTP. However, posttranslational modifications such as phos...

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Detalles Bibliográficos
Autores principales: Pronk, Manon C. A., Majolée, Jisca, Loregger, Anke, van Bezu, Jan S. M., Zelcer, Noam, Hordijk, Peter L., Kovačević, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589702/
https://www.ncbi.nlm.nih.gov/pubmed/30601691
http://dx.doi.org/10.1091/mbc.E18-04-0259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589702/
https://www.ncbi.nlm.nih.gov/pubmed/30601691
http://dx.doi.org/10.1091/mbc.E18-04-0259

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