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IL-1 in osteoarthritis: time for a critical review of the literature
The concept of interleukin-1 (IL-1) as a target in osteoarthritis (OA) has been an attractive one for many years. It is a highly potent inducer of cartilage degradation, causing the induction of mRNA and controlling the bioavailability of disease-relevant proteases such as ADAMTS5 and MMP13. It driv...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000 Research Limited
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589928/ https://www.ncbi.nlm.nih.gov/pubmed/31249675 http://dx.doi.org/10.12688/f1000research.18831.1 |