Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases

The prognosis of stage IVb non‐small cell lung cancer (NSCLC) patients with multiple distant metastases or involvement of different extra‐thoracic sites is poor. The prognosis following salvage surgery for patients with more than five metastases has been reported as most unfavourable. The following...

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Autores principales: Horio, Yoshitsugu, Mizuno, Tetsuya, Sakao, Yukinori, Inaba, Yoshitaka, Yatabe, Yasushi, Hida, Toyoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590094/
https://www.ncbi.nlm.nih.gov/pubmed/31285825
http://dx.doi.org/10.1002/rcr2.451
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author Horio, Yoshitsugu
Mizuno, Tetsuya
Sakao, Yukinori
Inaba, Yoshitaka
Yatabe, Yasushi
Hida, Toyoaki
author_facet Horio, Yoshitsugu
Mizuno, Tetsuya
Sakao, Yukinori
Inaba, Yoshitaka
Yatabe, Yasushi
Hida, Toyoaki
author_sort Horio, Yoshitsugu
collection PubMed
description The prognosis of stage IVb non‐small cell lung cancer (NSCLC) patients with multiple distant metastases or involvement of different extra‐thoracic sites is poor. The prognosis following salvage surgery for patients with more than five metastases has been reported as most unfavourable. The following case is of a 71‐year‐old man with a 9‐year survival duration after being diagnosed with stage IVb ALK‐rearranged lung adenocarcinoma, who was treated for 6 years with whole‐brain radiotherapy, pemetrexed‐based chemotherapy, ALK‐tyrosine kinase inhibitors (TKIs) including ceritinib and alectinib, and salvage sublobar resection of the primary lung cancer and who obtained treatment‐free remission (TFR) for more than 3 years following surgery.
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spelling pubmed-65900942019-07-08 Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases Horio, Yoshitsugu Mizuno, Tetsuya Sakao, Yukinori Inaba, Yoshitaka Yatabe, Yasushi Hida, Toyoaki Respirol Case Rep Case Reports The prognosis of stage IVb non‐small cell lung cancer (NSCLC) patients with multiple distant metastases or involvement of different extra‐thoracic sites is poor. The prognosis following salvage surgery for patients with more than five metastases has been reported as most unfavourable. The following case is of a 71‐year‐old man with a 9‐year survival duration after being diagnosed with stage IVb ALK‐rearranged lung adenocarcinoma, who was treated for 6 years with whole‐brain radiotherapy, pemetrexed‐based chemotherapy, ALK‐tyrosine kinase inhibitors (TKIs) including ceritinib and alectinib, and salvage sublobar resection of the primary lung cancer and who obtained treatment‐free remission (TFR) for more than 3 years following surgery. John Wiley & Sons, Ltd 2019-06-24 /pmc/articles/PMC6590094/ /pubmed/31285825 http://dx.doi.org/10.1002/rcr2.451 Text en © 2019 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Horio, Yoshitsugu
Mizuno, Tetsuya
Sakao, Yukinori
Inaba, Yoshitaka
Yatabe, Yasushi
Hida, Toyoaki
Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title_full Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title_fullStr Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title_full_unstemmed Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title_short Successful salvage surgery following multimodal therapy in a patient who harboured ALK‐rearranged advanced lung adenocarcinoma with multiple organ metastases
title_sort successful salvage surgery following multimodal therapy in a patient who harboured alk‐rearranged advanced lung adenocarcinoma with multiple organ metastases
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590094/
https://www.ncbi.nlm.nih.gov/pubmed/31285825
http://dx.doi.org/10.1002/rcr2.451
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