Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides

Endotoxin damage is an acute, multi-organ disease, the most typical symptoms of which are liver injury and inflammatory cytokine storm. Endotoxin tolerance is described as the pretreatment of lipopolysaccharides (LPS) before the toxin invasion, which is consistent with the adaptive response induced...

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Autores principales: Dong, Suhe, Qian, Wen, Liu, Tingting, Liu, Hu, Du, Jicong, Zhao, Hainan, Gao, Fu, Cai, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Potential Clinical Implication of LDR Hormesis and Adaptive Response
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590103/
https://www.ncbi.nlm.nih.gov/pubmed/31258453
http://dx.doi.org/10.1177/1559325819836355
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author Dong, Suhe
Qian, Wen
Liu, Tingting
Liu, Hu
Du, Jicong
Zhao, Hainan
Gao, Fu
Cai, Jianming
author_facet Dong, Suhe
Qian, Wen
Liu, Tingting
Liu, Hu
Du, Jicong
Zhao, Hainan
Gao, Fu
Cai, Jianming
author_sort Dong, Suhe
collection PubMed
description Endotoxin damage is an acute, multi-organ disease, the most typical symptoms of which are liver injury and inflammatory cytokine storm. Endotoxin tolerance is described as the pretreatment of lipopolysaccharides (LPS) before the toxin invasion, which is consistent with the adaptive response induced by low-dose radiation (LDR). In this study, we verified that LDR could resist the endotoxin damage by suppressing the increase of inflammatory cytokines, including interleukin 6, tumor necrosis factor, and NO, to improve the survival and relieve the inflammatory cell infiltration, in which low dose of LPS performed consistently with LDR.
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spelling pubmed-65901032019-06-28 Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides Dong, Suhe Qian, Wen Liu, Tingting Liu, Hu Du, Jicong Zhao, Hainan Gao, Fu Cai, Jianming Dose Response Potential Clinical Implication of LDR Hormesis and Adaptive Response Endotoxin damage is an acute, multi-organ disease, the most typical symptoms of which are liver injury and inflammatory cytokine storm. Endotoxin tolerance is described as the pretreatment of lipopolysaccharides (LPS) before the toxin invasion, which is consistent with the adaptive response induced by low-dose radiation (LDR). In this study, we verified that LDR could resist the endotoxin damage by suppressing the increase of inflammatory cytokines, including interleukin 6, tumor necrosis factor, and NO, to improve the survival and relieve the inflammatory cell infiltration, in which low dose of LPS performed consistently with LDR. SAGE Publications 2019-06-23 /pmc/articles/PMC6590103/ /pubmed/31258453 http://dx.doi.org/10.1177/1559325819836355 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Potential Clinical Implication of LDR Hormesis and Adaptive Response
Dong, Suhe
Qian, Wen
Liu, Tingting
Liu, Hu
Du, Jicong
Zhao, Hainan
Gao, Fu
Cai, Jianming
Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title_full Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title_fullStr Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title_full_unstemmed Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title_short Repeated 0.2-Gy γ-Ray Irradiation Attenuates the Inflammatory Process and Endotoxin Damage Induced by Lipopolysaccharides
title_sort repeated 0.2-gy γ-ray irradiation attenuates the inflammatory process and endotoxin damage induced by lipopolysaccharides
topic Potential Clinical Implication of LDR Hormesis and Adaptive Response
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590103/
https://www.ncbi.nlm.nih.gov/pubmed/31258453
http://dx.doi.org/10.1177/1559325819836355
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