Cargando…

Clinical outcomes of EGFR kinase domain duplication to targeted therapies in NSCLC

Kinase domain duplications of the epidermal growth factor receptor (EGFR‐KDD) have been identified and implicated to be oncogenic in nonsmall cell lung cancers (NSCLCs). However, its prevalence and clinical contributions in lung cancer are largely unknown. Here, we conducted a multicenter record rev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jinguang, Li, Xingya, Xue, Xingyang, Ou, Qiuxiang, Wu, Xue, Liang, Ying, Wang, Xiaonan, You, Ming, Shao, Yang W., Zhang, Zhihong, Zhang, Shucai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2018
Materias:	Cancer Genetics and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590137/ https://www.ncbi.nlm.nih.gov/pubmed/30255937 http://dx.doi.org/10.1002/ijc.31895

Ejemplares similares

Analysis of the lncRNA–miRNA–mRNA Network Reveals a Potential Regulatory Mechanism of EGFR-TKI Resistance in NSCLC
por: Ding, Dandan, et al.
Publicado: (2022)

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis
por: Zhou, Xuan, et al.
Publicado: (2022)

Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance
por: He, Yazhou, et al.
Publicado: (2021)

Rare mutation-dominant compound EGFR-positive NSCLC is associated with enriched kinase domain-resided variants of uncertain significance and poor clinical outcomes
por: Zhao, Weixin, et al.
Publicado: (2023)

Characteristics of genomic alterations of lung adenocarcinoma in young never‐smokers
por: Luo, Wenxin, et al.
Publicado: (2018)

Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population‐based cohort study
por: He, Yazhou, et al.
Publicado: (2019)

Clinical and molecular characteristics of kinase domain duplications across diverse cancer types in the Chinese population
por: Lai, Xiaojing, et al.
Publicado: (2022)

Germline variation in BRCA1/2 is highly ethnic‐specific: Evidence from over 30,000 Chinese hereditary breast and ovarian cancer patients
por: Bhaskaran, Shanmuga Priya, et al.
Publicado: (2019)

Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells
por: Cai, Mengdi, et al.
Publicado: (2018)

Ethnic‐specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population
por: Qin, Zixin, et al.
Publicado: (2022)

Long‐distance interaction of the integrated HPV fragment with MYC gene and 8q24.22 region upregulating the allele‐specific MYC expression in HeLa cells
por: Shen, Congle, et al.
Publicado: (2017)

Multiscale network analysis reveals molecular mechanisms and key regulators of the tumor microenvironment in gastric cancer
por: Song, Won‐Min, et al.
Publicado: (2019)

Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations
por: Sa, Jason K., et al.
Publicado: (2019)

ANO7 is associated with aggressive prostate cancer
por: Kaikkonen, Elina, et al.
Publicado: (2018)

The distribution of BRAF gene fusions in solid tumors and response to targeted therapy
por: Ross, Jeffrey S., et al.
Publicado: (2016)

Germline variants and somatic mutation signatures of breast cancer across populations of African and European ancestry in the US and Nigeria
por: Wang, Shengfeng, et al.
Publicado: (2019)

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium
por: Barrdahl, Myrto, et al.
Publicado: (2017)

FGFR1 tyrosine kinase domain duplication in pilocytic astrocytoma with anaplasia
por: Ballester, Leomar Y., et al.
Publicado: (2018)

Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome‐wide shRNA screen
por: Kurahara, Hiroshi, et al.
Publicado: (2016)

Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway
por: Sakai, Eiji, et al.
Publicado: (2015)

Molecular differences in the microsatellite stable phenotype between left‐sided and right‐sided colorectal cancer
por: Takahashi, Yayoi, et al.
Publicado: (2016)

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis
por: Bu, Rong, et al.
Publicado: (2016)

A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells
por: Hvichia, G.E., et al.
Publicado: (2016)

FANCM c.5101C>T mutation associates with breast cancer survival and treatment outcome
por: Kiiski, Johanna I., et al.
Publicado: (2016)

Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression
por: Rifatbegovic, Fikret, et al.
Publicado: (2017)

Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas
por: Agostini, Antonio, et al.
Publicado: (2018)

Single CpG hypermethylation, allele methylation errors, and decreased expression of multiple tumor suppressor genes in normal body cells of mutation‐negative early‐onset and high‐risk breast cancer patients
por: Böck, Julia, et al.
Publicado: (2018)

Distinct methylation profile of mucinous ovarian carcinoma reveals susceptibility to proteasome inhibitors
por: Liew, Phui‐Ly, et al.
Publicado: (2018)

Fountain of youth for squamous cell carcinomas? On the epigenetic age of non‐small cell lung cancer and corresponding tumor‐free lung tissues
por: Marwitz, Sebastian, et al.
Publicado: (2018)

Quantitative analysis of somatically acquired and constitutive uniparental disomy in gastrointestinal cancers
por: Torabi, Keyvan, et al.
Publicado: (2018)

Targeted RNA‐seq successfully identifies normal and pathogenic splicing events in breast/ovarian cancer susceptibility and Lynch syndrome genes
por: Brandão, Rita D., et al.
Publicado: (2019)

Detection of circulating microRNAs with Ago2 complexes to monitor the tumor dynamics of colorectal cancer patients during chemotherapy
por: Fuji, Tomokazu, et al.
Publicado: (2019)

Multigene panel sequencing of established and candidate melanoma susceptibility genes in a large cohort of Dutch non‐CDKN2A/CDK4 melanoma families
por: Potjer, Thomas P., et al.
Publicado: (2019)

Genetic variants in SLC22A3 contribute to the susceptibility to colorectal cancer
por: Ren, Anjing, et al.
Publicado: (2019)

Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer
por: Gargallo, Carla J., et al.
Publicado: (2018)

Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing
por: Girard, Elodie, et al.
Publicado: (2018)

DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort
por: van Leeuwen, Robert W., et al.
Publicado: (2018)

Molecular progression to cervical precancer, epigenetic switch or sequential model?
por: Nedjai, Belinda, et al.
Publicado: (2018)

CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
por: Vedeld, Hege Marie, et al.
Publicado: (2017)

Alcohol metabolism genes and risks of site‐specific cancers in Chinese adults: An 11‐year prospective study
por: Im, Pek Kei, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qh5sun99bok3sic6v2odb48upe