Novel dual‐action prodrug triggers apoptosis in glioblastoma cells by releasing a glutathione quencher and lysine‐specific histone demethylase 1A inhibitor

Targeting epigenetic mechanisms has shown promise against several cancers but has so far been unsuccessful against glioblastoma (GBM). Altered histone 3 lysine 4 methylation and increased lysine‐specific histone demethylase 1A (LSD1) expression in GBM tumours nonetheless suggest that epigenetic mech...

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Detalles Bibliográficos
Autores principales: Engel, Martin, Gee, Yi Sing, Cross, Dale, Maccarone, Alan, Heng, Benjamin, Hulme, Amy, Smith, Grady, Guillemin, Gilles J., Stringer, Brett W., Hyland, Christopher J. T., Ooi, Lezanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
ORIGINAL ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590141/
https://www.ncbi.nlm.nih.gov/pubmed/30592774
http://dx.doi.org/10.1111/jnc.14655

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