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UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases

Uveitis is an intraocular inflammatory disease which can lead to serious visual impairment. Genetic factors have been shown to be involved in its development. However, few databases have focused on the information of associations between single nucleotide polymorphisms (SNPs) and uveitis. To discove...

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Autores principales: Wang, Qingfeng, Su, Guannan, Tan, Xiao, Deng, Jing, Du, Liping, Huang, Xinyue, Lv, Meng, Yi, Shenglan, Hou, Shengping, Kijlstra, Aize, Yang, Peizeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590147/
https://www.ncbi.nlm.nih.gov/pubmed/30614601
http://dx.doi.org/10.1002/humu.23702
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author Wang, Qingfeng
Su, Guannan
Tan, Xiao
Deng, Jing
Du, Liping
Huang, Xinyue
Lv, Meng
Yi, Shenglan
Hou, Shengping
Kijlstra, Aize
Yang, Peizeng
author_facet Wang, Qingfeng
Su, Guannan
Tan, Xiao
Deng, Jing
Du, Liping
Huang, Xinyue
Lv, Meng
Yi, Shenglan
Hou, Shengping
Kijlstra, Aize
Yang, Peizeng
author_sort Wang, Qingfeng
collection PubMed
description Uveitis is an intraocular inflammatory disease which can lead to serious visual impairment. Genetic factors have been shown to be involved in its development. However, few databases have focused on the information of associations between single nucleotide polymorphisms (SNPs) and uveitis. To discover the exact genetic background of uveitis, we developed an SNP database specific for uveitis, “UVEOGENE,” which includes 370 genes and 918 SNPs covering 14 uveitis entities and 40 populations from 286 PubMed English‐language papers. Stratification analyses by gender, HLA status, and different clinical features were also extracted from the publications. As a result, 371 associations were judged as “statistically significant.” These associations were also shared with Global Variome shared Leiden Open Variation Database (LOVD) (https://databases.lovd.nl/shared/genes). Based on these associations, we investigated the genetic relationship among three widely studied uveitis entities including Behcet's disease (BD), Vogt–Koyanagi–Harada (VKH) disease, and acute anterior uveitis (AAU). Furthermore, “UVEOGENE” can be used as a reliable and informative resource to identify similarities as well as differences in the genetic susceptibility among uveitis and other autoimmune diseases. UVEOGENE is freely accessible at http://www.uvogene.com.
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spelling pubmed-65901472019-07-08 UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases Wang, Qingfeng Su, Guannan Tan, Xiao Deng, Jing Du, Liping Huang, Xinyue Lv, Meng Yi, Shenglan Hou, Shengping Kijlstra, Aize Yang, Peizeng Hum Mutat Databases Uveitis is an intraocular inflammatory disease which can lead to serious visual impairment. Genetic factors have been shown to be involved in its development. However, few databases have focused on the information of associations between single nucleotide polymorphisms (SNPs) and uveitis. To discover the exact genetic background of uveitis, we developed an SNP database specific for uveitis, “UVEOGENE,” which includes 370 genes and 918 SNPs covering 14 uveitis entities and 40 populations from 286 PubMed English‐language papers. Stratification analyses by gender, HLA status, and different clinical features were also extracted from the publications. As a result, 371 associations were judged as “statistically significant.” These associations were also shared with Global Variome shared Leiden Open Variation Database (LOVD) (https://databases.lovd.nl/shared/genes). Based on these associations, we investigated the genetic relationship among three widely studied uveitis entities including Behcet's disease (BD), Vogt–Koyanagi–Harada (VKH) disease, and acute anterior uveitis (AAU). Furthermore, “UVEOGENE” can be used as a reliable and informative resource to identify similarities as well as differences in the genetic susceptibility among uveitis and other autoimmune diseases. UVEOGENE is freely accessible at http://www.uvogene.com. John Wiley and Sons Inc. 2019-01-16 2019-03 /pmc/articles/PMC6590147/ /pubmed/30614601 http://dx.doi.org/10.1002/humu.23702 Text en © 2019 The Authors. Human Mutation published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Databases
Wang, Qingfeng
Su, Guannan
Tan, Xiao
Deng, Jing
Du, Liping
Huang, Xinyue
Lv, Meng
Yi, Shenglan
Hou, Shengping
Kijlstra, Aize
Yang, Peizeng
UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title_full UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title_fullStr UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title_full_unstemmed UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title_short UVEOGENE: An SNP database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
title_sort uveogene: an snp database for investigations on genetic factors associated with uveitis and their relationship with other systemic autoimmune diseases
topic Databases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590147/
https://www.ncbi.nlm.nih.gov/pubmed/30614601
http://dx.doi.org/10.1002/humu.23702
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