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Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats

OBJECTIVE: Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. METHODS: For 3 weeks, 7‐week‐old male rats were offered either chow only or...

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Autores principales: Peris‐Sampedro, Fiona, Mounib, Myriam, Schéle, Erik, Edvardsson, Christian E., Stoltenborg, Iris, Adan, Roger A. H., Dickson, Suzanne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590171/
https://www.ncbi.nlm.nih.gov/pubmed/30699240
http://dx.doi.org/10.1002/oby.22381
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author Peris‐Sampedro, Fiona
Mounib, Myriam
Schéle, Erik
Edvardsson, Christian E.
Stoltenborg, Iris
Adan, Roger A. H.
Dickson, Suzanne L.
author_facet Peris‐Sampedro, Fiona
Mounib, Myriam
Schéle, Erik
Edvardsson, Christian E.
Stoltenborg, Iris
Adan, Roger A. H.
Dickson, Suzanne L.
author_sort Peris‐Sampedro, Fiona
collection PubMed
description OBJECTIVE: Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. METHODS: For 3 weeks, 7‐week‐old male rats were offered either chow only or free‐choice high‐fat diets differing in their added sugar: no sugar, sucrose, or glucose. In a second experiment, after 2 weeks on the diets, rats were switched from high sucrose to high glucose for two additional weeks. Metabolic end points included body weight, food intake, food choice, glycemic control, metabolic hormones, fat pad weight, brown adipose tissue weight, and gene expression. Behavioral analysis included locomotor and anxiety‐like activity in the open field and elevated plus maze. RESULTS: Both sugar diets enhanced adiposity and induced hyperphagia, favoring unhealthier dietary selection above that of the control diets (chow or free‐choice high‐fat with no sugar). Despite isocaloric intake in the sugar‐containing diets, offering glucose instead of sucrose was associated with improved insulin sensitivity. The sugar‐containing diets reduced activity (but with movements of increased velocity) and induced an anxiety‐like phenotype. CONCLUSIONS: Although free‐choice diets negatively impacted on metabolism and anxiety‐like behavior, replacing sucrose with glucose improved insulin sensitivity and may therefore be better for health.
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spelling pubmed-65901712019-07-08 Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats Peris‐Sampedro, Fiona Mounib, Myriam Schéle, Erik Edvardsson, Christian E. Stoltenborg, Iris Adan, Roger A. H. Dickson, Suzanne L. Obesity (Silver Spring) Original Articles OBJECTIVE: Rats were exposed to free‐choice diets (fat plus one of two different sugar solutions, glucose or sucrose), and the metabolic consequences and impact on locomotor activity and anxiety‐like behavior were explored. METHODS: For 3 weeks, 7‐week‐old male rats were offered either chow only or free‐choice high‐fat diets differing in their added sugar: no sugar, sucrose, or glucose. In a second experiment, after 2 weeks on the diets, rats were switched from high sucrose to high glucose for two additional weeks. Metabolic end points included body weight, food intake, food choice, glycemic control, metabolic hormones, fat pad weight, brown adipose tissue weight, and gene expression. Behavioral analysis included locomotor and anxiety‐like activity in the open field and elevated plus maze. RESULTS: Both sugar diets enhanced adiposity and induced hyperphagia, favoring unhealthier dietary selection above that of the control diets (chow or free‐choice high‐fat with no sugar). Despite isocaloric intake in the sugar‐containing diets, offering glucose instead of sucrose was associated with improved insulin sensitivity. The sugar‐containing diets reduced activity (but with movements of increased velocity) and induced an anxiety‐like phenotype. CONCLUSIONS: Although free‐choice diets negatively impacted on metabolism and anxiety‐like behavior, replacing sucrose with glucose improved insulin sensitivity and may therefore be better for health. John Wiley and Sons Inc. 2019-01-30 2019-03 /pmc/articles/PMC6590171/ /pubmed/30699240 http://dx.doi.org/10.1002/oby.22381 Text en © 2019 The Authors Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS) This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Peris‐Sampedro, Fiona
Mounib, Myriam
Schéle, Erik
Edvardsson, Christian E.
Stoltenborg, Iris
Adan, Roger A. H.
Dickson, Suzanne L.
Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title_full Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title_fullStr Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title_full_unstemmed Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title_short Impact of Free‐Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety‐Like Behavior in Rats
title_sort impact of free‐choice diets high in fat and different sugars on metabolic outcome and anxiety‐like behavior in rats
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590171/
https://www.ncbi.nlm.nih.gov/pubmed/30699240
http://dx.doi.org/10.1002/oby.22381
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