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Developing role of B cells in the pathogenesis and treatment of chronic GVHD

Chronic graft‐versus‐host disease (cGVHD) is a major complication affecting the long‐term survival of patients after allogeneic haematopoietic stem cell transplantation. The mechanism of cGVHD is unclear, and while previous studies have primarily focused on T cells, the role of B cells in the pathog...

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Detalles Bibliográficos
Autores principales: Li, Xiaoping, Gao, Qiangguo, Feng, Yimei, Zhang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590173/
https://www.ncbi.nlm.nih.gov/pubmed/30585319
http://dx.doi.org/10.1111/bjh.15719
Descripción
Sumario:Chronic graft‐versus‐host disease (cGVHD) is a major complication affecting the long‐term survival of patients after allogeneic haematopoietic stem cell transplantation. The mechanism of cGVHD is unclear, and while previous studies have primarily focused on T cells, the role of B cells in the pathogenesis of cGVHD has been less reported. However, current studies on cGVHD are increasingly focused on the important role of B cells. In this review, we will introduce the newest studies and examine the role of B cells in cGVHD in detail with respect to the following aspects: altered B cell subpopulations, aberrant B cell signalling pathways, autoantibodies and T‐B cell interactions. Treatment strategies for the targeting of B cells during cGVHD will also be discussed.