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Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization Across Channels with QSC Beads
Receptor occupancy, the ratio between amount of drug bound and amount of total receptor on single cells, is a biomarker for treatment response to therapeutic monoclonal antibodies. Receptor occupancy is traditionally measured by flow cytometry. However, spectral overlap in flow cytometry limits the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley & Sons, Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590231/ https://www.ncbi.nlm.nih.gov/pubmed/30688025 http://dx.doi.org/10.1002/cyto.a.23723 |