Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy

C3 glomerulopathy (C3G) is an umbrella classification for severe renal diseases characterized by predominant staining for complement component C3 in the glomeruli. The disease is caused by a dysregulation of the alternative pathway (AP) of the complement system. In more than half of C3G patients C3...

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Detalles Bibliográficos
Autores principales: Michels, Marloes A. H. M., van de Kar, Nicole C. A. J., van den Bos, Ramon M., van der Velden, Thea J. A. M., van Kraaij, Sanne A. W., Sarlea, Sebastian A., Gracchi, Valentina, Oosterveld, Michiel J. S., Volokhina, Elena B., van den Heuvel, Lambertus P. W. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590259/
https://www.ncbi.nlm.nih.gov/pubmed/31263464
http://dx.doi.org/10.3389/fimmu.2019.01350

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