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Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome

Aims of this study were to investigate white matter (WM) and thalamus microstructure 72 hr and 3 months after mild traumatic brain injury (TBI) with diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI), and to relate DKI and DTI findings to postconcussional syndrome (PCS). Twenty‐five...

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Autores principales: Karlsen, Rune Hatlestad, Einarsen, Cathrine, Moe, Hans Kristian, Håberg, Asta Kristine, Vik, Anne, Skandsen, Toril, Eikenes, Live
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590310/
https://www.ncbi.nlm.nih.gov/pubmed/30675907
http://dx.doi.org/10.1002/jnr.24383
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author Karlsen, Rune Hatlestad
Einarsen, Cathrine
Moe, Hans Kristian
Håberg, Asta Kristine
Vik, Anne
Skandsen, Toril
Eikenes, Live
author_facet Karlsen, Rune Hatlestad
Einarsen, Cathrine
Moe, Hans Kristian
Håberg, Asta Kristine
Vik, Anne
Skandsen, Toril
Eikenes, Live
author_sort Karlsen, Rune Hatlestad
collection PubMed
description Aims of this study were to investigate white matter (WM) and thalamus microstructure 72 hr and 3 months after mild traumatic brain injury (TBI) with diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI), and to relate DKI and DTI findings to postconcussional syndrome (PCS). Twenty‐five patients (72 hr = 24; 3 months = 23) and 22 healthy controls were recruited, and DKI and DTI data were analyzed with Tract‐Based Spatial Statistics (TBSS) and a region‐of‐interest (ROI) approach. Patients were categorized into PCS or non‐PCS 3 months after injury according to the ICD‐10 research criteria for PCS. In TBSS analysis, significant differences between patients and controls were seen in WM, both in the acute stage and 3 months after injury. Fractional anisotropy (FA) reductions were more widespread than kurtosis fractional anisotropy (KFA) reductions in the acute stage, while KFA reductions were more widespread than the FA reductions at 3 months, indicating the complementary roles of DKI and DTI. When comparing patients with PCS (n = 9), without PCS (n = 16), and healthy controls, in the ROI analyses, no differences were found in the acute DKI and DTI metrics. However, near‐significant differences were observed for several DKI metrics obtained in WM and thalamus concurrently with symptom assessment (3 months after injury). Our findings indicate a combined utility of DKI and DTI in detecting WM microstructural alterations after mild TBI. Moreover, PCS may be associated with evolving alterations in brain microstructure, and DKI may be a promising tool to detect such changes.
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spelling pubmed-65903102019-07-08 Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome Karlsen, Rune Hatlestad Einarsen, Cathrine Moe, Hans Kristian Håberg, Asta Kristine Vik, Anne Skandsen, Toril Eikenes, Live J Neurosci Res Research Articles Aims of this study were to investigate white matter (WM) and thalamus microstructure 72 hr and 3 months after mild traumatic brain injury (TBI) with diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI), and to relate DKI and DTI findings to postconcussional syndrome (PCS). Twenty‐five patients (72 hr = 24; 3 months = 23) and 22 healthy controls were recruited, and DKI and DTI data were analyzed with Tract‐Based Spatial Statistics (TBSS) and a region‐of‐interest (ROI) approach. Patients were categorized into PCS or non‐PCS 3 months after injury according to the ICD‐10 research criteria for PCS. In TBSS analysis, significant differences between patients and controls were seen in WM, both in the acute stage and 3 months after injury. Fractional anisotropy (FA) reductions were more widespread than kurtosis fractional anisotropy (KFA) reductions in the acute stage, while KFA reductions were more widespread than the FA reductions at 3 months, indicating the complementary roles of DKI and DTI. When comparing patients with PCS (n = 9), without PCS (n = 16), and healthy controls, in the ROI analyses, no differences were found in the acute DKI and DTI metrics. However, near‐significant differences were observed for several DKI metrics obtained in WM and thalamus concurrently with symptom assessment (3 months after injury). Our findings indicate a combined utility of DKI and DTI in detecting WM microstructural alterations after mild TBI. Moreover, PCS may be associated with evolving alterations in brain microstructure, and DKI may be a promising tool to detect such changes. John Wiley and Sons Inc. 2019-01-24 2019-05 /pmc/articles/PMC6590310/ /pubmed/30675907 http://dx.doi.org/10.1002/jnr.24383 Text en © 2019 The Authors. Journal of Neuroscience Research Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Karlsen, Rune Hatlestad
Einarsen, Cathrine
Moe, Hans Kristian
Håberg, Asta Kristine
Vik, Anne
Skandsen, Toril
Eikenes, Live
Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title_full Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title_fullStr Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title_full_unstemmed Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title_short Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
title_sort diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590310/
https://www.ncbi.nlm.nih.gov/pubmed/30675907
http://dx.doi.org/10.1002/jnr.24383
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